Assessment of Structural Intolerance and Durability
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3v5l ITK crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 542 1.86Å AUTH L.R.MCLEAN,Y.ZHANG,N.ZAIDI,X.BI,R.WANG,R.DHARANIPRAGADA,AUTH 2 J.G.JURCAK,T.A.GILLESPY,Z.ZHAO,K.Y.MUSICK,Y.M.CHOI,AUTH 3 M.BARRAGUE,J.PEPPARD,M.SMICKER,M.DUGUID,A.PARKAR,J.FORDHAM,AUTH 4 D.KOMINOSTITL X-RAY CRYSTALLOGRAPHIC STRUCTURE-BASED DESIGN OF SELECTIVETITL 2 THIENOPYRAZOLE INHIBITORS FOR INTERLEUKIN-2-INDUCIBLETITL 3 TYROSINE KINASE.REF BIOORG.MED.CHEM.LETT. V. 22 3296 2012REFN ISSN 0960-894XPMID 22464456DOI 10.1016/J.BMCL.2012.03.016 Variant Set Distributions Ripley’s […]
General Structure Information 2enn PRKCQ solution structure of the first c1 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C1 DOMAIN FROMTITL 2 HUMAN PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yrk PRKCD the c2 domain of pkc is a new phospho-tyrosine binding domain 1.7Å AUTH C.H.BENES,N.WU,A.E.ELIA,T.DHARIA,L.C.CANTLEY,AUTH 2 S.P.SOLTOFFTITL THE C2 DOMAIN OF PKCDELTA IS A PHOSPHOTYROSINETITL 2 BINDING DOMAIN.REF CELL(CAMBRIDGE,MASS.) V. 121 271 2005REFN ISSN 0092-8674PMID 15851022DOI 10.1016/J.CELL.2005.02.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2a2d GALK2 x-ray structure of human n-acetyl galactosamine kinase complexed with mn-amppnp and n-acetyl glactosamine 2.2Å AUTH J.B.THODEN,H.M.HOLDENTITL THE MOLECULAR ARCHITECTURE OF HUMANTITL 2 N-ACETYLGALACTOSAMINE KINASE.REF J.BIOL.CHEM. V. 280 32784 2005REFN ISSN 0021-9258PMID 16006554DOI 10.1074/JBC.M505730200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a2d GALK2 x-ray structure of human n-acetyl galactosamine kinase complexed with mn-amppnp and n-acetyl glactosamine 2.2Å AUTH J.B.THODEN,H.M.HOLDENTITL THE MOLECULAR ARCHITECTURE OF HUMANTITL 2 N-ACETYLGALACTOSAMINE KINASE.REF J.BIOL.CHEM. V. 280 32784 2005REFN ISSN 0021-9258PMID 16006554DOI 10.1074/JBC.M505730200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a2d GALK2 x-ray structure of human n-acetyl galactosamine kinase complexed with mn-amppnp and n-acetyl glactosamine 2.2Å AUTH J.B.THODEN,H.M.HOLDENTITL THE MOLECULAR ARCHITECTURE OF HUMANTITL 2 N-ACETYLGALACTOSAMINE KINASE.REF J.BIOL.CHEM. V. 280 32784 2005REFN ISSN 0021-9258PMID 16006554DOI 10.1074/JBC.M505730200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c74 YWHAH 14-3-3 protein eta (human) complexed to peptide 2.7Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1waw CHIT1 specificity and affinity of natural product cyclopentapeptide inhibitor argadin against human chitinase 1.75Å AUTH F.V.RAO,D.R.HOUSTON,R.G.BOOT,J.M.F.G.AERTS,M.HODKINSON,AUTH 2 D.J.ADAMS,K.SHIOMI,S.OMURA,D.M.F.VAN AALTENTITL SPECIFICITY AND AFFINITY OF NATURAL PRODUCTTITL 2 CYCLOPENTAPEPTIDE INHIBITORS AGAINST ASPERGILLUS FUMIGATUS,TITL 3 HUMAN AND BACTERIAL CHITINASESREF CHEM.BIOL. V. 12 65 2005REFN ISSN 1074-5521PMID 15664516DOI 10.1016/J.CHEMBIOL.2004.10.013 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1waw CHIT1 specificity and affinity of natural product cyclopentapeptide inhibitor argadin against human chitinase 1.75Å AUTH F.V.RAO,D.R.HOUSTON,R.G.BOOT,J.M.F.G.AERTS,M.HODKINSON,AUTH 2 D.J.ADAMS,K.SHIOMI,S.OMURA,D.M.F.VAN AALTENTITL SPECIFICITY AND AFFINITY OF NATURAL PRODUCTTITL 2 CYCLOPENTAPEPTIDE INHIBITORS AGAINST ASPERGILLUS FUMIGATUS,TITL 3 HUMAN AND BACTERIAL CHITINASESREF CHEM.BIOL. V. 12 65 2005REFN ISSN 1074-5521PMID 15664516DOI 10.1016/J.CHEMBIOL.2004.10.013 Variant Set Distributions Ripley’s K Analysis […]