General Structure Information
| PDB ID | 1yrk |
| HGNC Gene Label(s) | PRKCD |
| Structure Name | the c2 domain of pkc |
| Resolution | 1.7Å |
| Reference | AUTH C.H.BENES,N.WU,A.E.ELIA,T.DHARIA,L.C.CANTLEY,AUTH 2 S.P.SOLTOFFTITL THE C2 DOMAIN OF PKCDELTA IS A PHOSPHOTYROSINETITL 2 BINDING DOMAIN.REF CELL(CAMBRIDGE,MASS.) V. 121 271 2005REFN ISSN 0092-8674PMID 15851022DOI 10.1016/J.CELL.2005.02.019 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 123 |
| Number Of SNVs | 22 |
| Number Of Permutations | 11939 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.463 |
| p-value | 0.614 |
COSMIC
| Number Of Residues | 123 |
| Number Of SNVs | 3 |
| Number Of Permutations | 76 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.24 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 22 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.273 |
| p-value | 0.643 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
