Assessment of Structural Intolerance and Durability
General Structure Information 2qw4 NR4A1 human nr4a1 ligand-binding domain 2.8Å AUTH J.R.MIN,A.SCHUETZ,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN NR4A1 LIGAND-BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1h9u RXRB the structure of the human retinoid-x-receptor beta ligand binding domain in complex with the specific synthetic agonist lg100268 2.7Å AUTH J.D.LOVE,J.T.GOOCH,S.BENKO,C.LI,L.NAGY,AUTH 2 V.K.K.CHATTERJEE,R.M.EVANS,J.W.R.SCHWABETITL THE STRUCTURAL BASIS FOR THE SPECIFICITY OFTITL 2 RETINOID-X RECEPTOR-SELECTIVE AGONISTS: NEWTITL 3 INSIGHTS INTO THE ROLE OF HELIX H12REF J.BIOL.CHEM. V. 277 11385 2002REFN ISSN 0021-9258PMID […]
General Structure Information 1ga5 NR1D1 crystal structure of the orphan nuclear receptor rev- erb(alpha) dna-binding domain bound to its cognate response element 2.4Å AUTH M.L.SIERK,Q.ZHAO,F.RASTINEJADTITL DNA DEFORMABILITY AS A RECOGNITION FEATURE IN THETITL 2 REVERB RESPONSE ELEMENTREF BIOCHEMISTRY V. 40 12833 2001REFN ISSN 0006-2960PMID 11669620DOI 10.1021/BI011086R Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4dm8 RARB crystal structure of rarb lbd in complex with 9cis retinoic acid 2.3Å AUTH J.OSZ,Y.BRELIVET,C.PELUSO-ILTIS,V.CURA,S.EILER,M.RUFF,AUTH 2 W.BOURGUET,N.ROCHEL,D.MORASTITL STRUCTURAL BASIS FOR A MOLECULAR ALLOSTERIC CONTROLTITL 2 MECHANISM OF COFACTOR BINDING TO NUCLEAR RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 109 E588 2012REFN ISSN 0027-8424PMID 22355136DOI 10.1073/PNAS.1118192109 Variant Set Distributions Mapped Variants
General Structure Information 2aa6 NR3C2 mineralocorticoid receptor s810l mutant with bound progesterone 1.95Å AUTH R.K.BLEDSOE,K.P.MADAUSS,J.A.HOLT,C.J.APOLITO,AUTH 2 M.H.LAMBERT,K.H.PEARCE,T.B.STANLEY,E.L.STEWART,AUTH 3 R.P.TRUMP,T.M.WILLSON,S.P.WILLIAMSTITL A LIGAND-MEDIATED HYDROGEN BOND NETWORK REQUIREDTITL 2 FOR THE ACTIVATION OF THE MINERALOCORTICOIDTITL 3 RECEPTORREF J.BIOL.CHEM. V. 280 31283 2005REFN ISSN 0021-9258PMID 15967794DOI 10.1074/JBC.M504098200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1kb4 VDR crystal structure of vdr dna-binding domain bound to a canonical direct repeat with three base pair spacer (dr3) response element 2.8Å AUTH P.L.SHAFFER,D.T.GEWIRTHTITL STRUCTURAL BASIS OF VDR-DNA INTERACTIONS ON DIRECTTITL 2 REPEAT RESPONSE ELEMENTS.REF EMBO J. V. 21 2242 2002REFN ISSN 0261-4189PMID 11980721DOI 10.1093/EMBOJ/21.9.2242 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 1dsz RARA structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1 1.7Å AUTH F.RASTINEJAD,T.WAGNER,Q.ZHAO,S.KHORASANIZADEHTITL STRUCTURE OF THE RXR-RAR DNA-BINDING COMPLEX ONTITL 2 THE RETINOIC ACID RESPONSE ELEMENT DR1.REF EMBO J. V. 19 1045 2000REFN ISSN 0261-4189PMID 10698945DOI 10.1093/EMBOJ/19.5.1045 Variant Set Distributions Mapped Variants
General Structure Information 1a28 PGR hormone-bound human progesterone receptor ligand-binding domain 1.8Å AUTH S.P.WILLIAMS,P.B.SIGLERTITL ATOMIC STRUCTURE OF PROGESTERONE COMPLEXED WITHTITL 2 ITS RECEPTOR.REF NATURE V. 393 392 1998REFN ISSN 0028-0836PMID 9620806DOI 10.1038/30775 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ilz THRA structure of tr-alfa bound to selective thyromimetic gc-1 in p212121 space group 1.85Å AUTH L.BLEICHER,R.APARICIO,F.M.NUNES,L.MARTINEZ,S.M.GOMES DIAS,AUTH 2 A.C.FIGUEIRA,M.A.SANTOS,W.H.VENTURELLI,R.DA SILVA,AUTH 3 P.M.DONATE,F.A.NEVES,L.A.SIMEONI,J.D.BAXTER,P.WEBB,AUTH 4 M.S.SKAF,I.POLIKARPOVTITL STRUCTURAL BASIS OF GC-1 SELECTIVITY FOR THYROID HORMONETITL 2 RECEPTOR ISOFORMS.REF BMC STRUCT.BIOL. V. 8 8 2008REFN ESSN 1472-6807PMID 18237438DOI 10.1186/1472-6807-8-8 Variant Set Distributions Mapped Variants
General Structure Information 3d24 ESRRA crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1alpha box3 peptide (pgc-1alpha) 2.11Å AUTH H.GRESCHIK,M.ALTHAGE,R.FLAIG,Y.SATO,V.CHAVANT,AUTH 2 C.PELUSO-ILTIS,L.CHOULIER,P.CRONET,N.ROCHEL,AUTH 3 R.SCHULE,P.E.STROMSTEDT,D.MORASTITL COMMUNICATION BETWEEN THE ERR{ALPHA} HOMODIMERTITL 2 INTERFACE AND THE PGC-1{ALPHA} BINDING SURFACE VIATITL 3 THE HELIX 8-9 LOOP.REF J.BIOL.CHEM. V. […]