General Structure Information
| PDB ID | 1a28 |
| HGNC Gene Label(s) | PGR |
| Structure Name | hormone-bound human progesterone receptor ligand-binding domain |
| Resolution | 1.8Å |
| Reference | AUTH S.P.WILLIAMS,P.B.SIGLERTITL ATOMIC STRUCTURE OF PROGESTERONE COMPLEXED WITHTITL 2 ITS RECEPTOR.REF NATURE V. 393 392 1998REFN ISSN 0028-0836PMID 9620806DOI 10.1038/30775 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 251 |
| Number Of SNVs | 32 |
| Number Of Permutations | 4322 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.135 |
| p-value | 0.003 |
COSMIC
| Number Of Residues | 251 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1057 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.1 |
| p-value | 0.971 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 32 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.172 |
| p-value | 0.032 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
