General Structure Information
| PDB ID | 2aa6 |
| HGNC Gene Label(s) | NR3C2 |
| Structure Name | mineralocorticoid receptor s810l mutant with bound progesterone |
| Resolution | 1.95Å |
| Reference | AUTH R.K.BLEDSOE,K.P.MADAUSS,J.A.HOLT,C.J.APOLITO,AUTH 2 M.H.LAMBERT,K.H.PEARCE,T.B.STANLEY,E.L.STEWART,AUTH 3 R.P.TRUMP,T.M.WILLSON,S.P.WILLIAMSTITL A LIGAND-MEDIATED HYDROGEN BOND NETWORK REQUIREDTITL 2 FOR THE ACTIVATION OF THE MINERALOCORTICOIDTITL 3 RECEPTORREF J.BIOL.CHEM. V. 280 31283 2005REFN ISSN 0021-9258PMID 15967794DOI 10.1074/JBC.M504098200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 259 |
| Number Of SNVs | 30 |
| Number Of Permutations | 8744 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.223 |
| p-value | 0.005 |
ClinVar
| Number Of Residues | 259 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1342 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.8 |
| p-value | 0.368 |
COSMIC
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 30 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.322 |
| p-value | 0.228 |
Cosmic vs. ExAC
