Assessment of Structural Intolerance and Durability
General Structure Information 4gqb WDR77 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Mapped Variants
General Structure Information 4hc4 PRMT6 human hmt1 hnrnp methyltransferase-like protein 6 (s. cerevisiae) 1.97Å AUTH H.ZENG,A.DONG,H.HE,M.EL BAKKOURI,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4lec METTL21A human methyltransferase-like protein 21a 2.28Å AUTH H.ZENG,A.DONG,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKETITL 2 PROTEIN 21A IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rjw EHMT2 crystal structure of histone lysine methyltransferase g9a with an inhibitor 2.56Å AUTH M.VEDADI,D.BARSYTE-LOVEJOY,F.LIU,S.RIVAL-GERVIER,AUTH 2 A.ALLALI-HASSANI,V.LABRIE,T.J.WIGLE,P.A.DIMAGGIO,G.A.WASNEY,AUTH 3 A.SIARHEYEVA,A.DONG,W.TEMPEL,S.C.WANG,X.CHEN,I.CHAU,AUTH 4 T.J.MANGANO,X.P.HUANG,C.D.SIMPSON,S.G.PATTENDEN,J.L.NORRIS,AUTH 5 D.B.KIREEV,A.TRIPATHY,A.EDWARDS,B.L.ROTH,W.P.JANZEN,AUTH 6 B.A.GARCIA,A.PETRONIS,J.ELLIS,P.J.BROWN,S.V.FRYE,AUTH 7 C.H.ARROWSMITH,J.JINTITL A CHEMICAL PROBE SELECTIVELY INHIBITS G9A AND GLPTITL 2 METHYLTRANSFERASE ACTIVITY IN CELLS.REF NAT.CHEM.BIOL. V. 7 566 2011REFN ISSN 1552-4450PMID 21743462DOI 10.1038/NCHEMBIO.599 Variant Set Distributions […]
General Structure Information 3qxy SETD6 human setd6 in complex with rela lys310 2.09Å AUTH Y.CHANG,D.LEVY,J.R.HORTON,J.PENG,X.ZHANG,O.GOZANI,X.CHENGTITL STRUCTURAL BASIS OF SETD6-MEDIATED REGULATION OF THE NF-KBTITL 2 NETWORK VIA METHYL-LYSINE SIGNALING.REF NUCLEIC ACIDS RES. V. 39 6380 2011REFN ISSN 0305-1048PMID 21515635DOI 10.1093/NAR/GKR256 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fmw TRMT10A crystal structure of methyltransferase domain of human rna (guanine-9- ) methyltransferase domain containing protein 2 2.0Å AUTH H.ZENG,A.DONG,P.LOPPNAU,W.TEMPEL,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,H.WUTITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNATITL 2 (GUANINE-9-) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n48 CMTR1 cap-specific mrna (nucleoside-2-o-)-methyltransferase 1 protein in complex with capped rna fragment 2.7Å AUTH M.SMIETANSKI,M.WERNER,E.PURTA,K.H.KAMINSKA,J.STEPINSKI,AUTH 2 E.DARZYNKIEWICZ,M.NOWOTNY,J.M.BUJNICKITITL STRUCTURAL ANALYSIS OF HUMAN 2-O-RIBOSE METHYLTRANSFERASESTITL 2 INVOLVED IN MRNA CAP STRUCTURE FORMATION.REF NAT COMMUN V. 5 3004 2014REFN ESSN 2041-1723PMID 24402442DOI 10.1038/NCOMMS4004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1h3i SETD7 crystal structure of the histone methyltransferase set7/9 2.1Å AUTH J.R.WILSON,C.JING,P.A.WALKER,S.R.MARTIN,S.A.HOWELL,AUTH 2 G.M.BLACKBURN,S.J.GAMBLIN,B.XIAOTITL CRYSTAL STRUCTURE AND FUNCTIONAL ANALYSIS OF THETITL 2 HISTONE METHYLTRANSFERASE SET7/9REF CELL(CAMBRIDGE,MASS.) V. 111 105 2002REFN ISSN 0092-8674PMID 12372304DOI 10.1016/S0092-8674(02)00964-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3smt SETD3 crystal structure of human set domain-containing protein3 2.04Å AUTH H.ZENG,A.DONG,J.R.WALKER,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF HUMAN SET DOMAIN-CONTAINING PROTEIN3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ekg DOT1L crystal structure of dot1l in complex with epz003696 2.8Å AUTH A.BASAVAPATHRUNI,L.JIN,S.R.DAIGLE,C.R.MAJER,C.A.THERKELSEN,AUTH 2 T.J.WIGLE,K.W.KUNTZ,R.CHESWORTH,R.M.POLLOCK,M.P.SCOTT,AUTH 3 M.P.MOYER,V.M.RICHON,R.A.COPELAND,E.J.OLHAVATITL CONFORMATIONAL ADAPTATION DRIVES POTENT, SELECTIVE ANDTITL 2 DURABLE INHIBITION OF THE HUMAN PROTEIN METHYLTRANSFERASETITL 3 DOT1L.REF CHEM.BIOL.DRUG DES. V. 80 971 2012REFN ISSN 1747-0277PMID 22978415DOI 10.1111/CBDD.12050 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]