Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3rsn ASH2L crystal structure of the n-terminal region of human ash2l 2.1Å AUTH Y.CHEN,B.WAN,K.C.WANG,F.CAO,Y.YANG,A.PROTACIO,Y.DOU,AUTH 2 H.Y.CHANG,M.LEITITL CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF HUMAN ASH2LTITL 2 SHOWS A WINGED-HELIX MOTIF INVOLVED IN DNA BINDING.REF EMBO REP. V. 12 797 2011REFN ISSN 1469-221XPMID 21660059DOI 10.1038/EMBOR.2011.101 Variant Set Distributions Mapped Variants
General Structure Information 3iei LCMT1 crystal structure of human leucine carboxylmethyltransferase-1 in complex with s-adenosyl homocysteine 1.9Å AUTH V.STANEVICH,L.JIANG,K.A.SATYSHUR,Y.LI,P.D.JEFFREY,Z.LI,AUTH 2 M.F.SEMMELHACK,Y.XINGTITL STRUCTURAL INSIGHTS INTO NOVEL FUNCTIONS OF A PRO-SURVIVALTITL 2 PP2A-SPECIFIC METHYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qkj DNMT3B the pwwp domain of human dna (cytosine-5-)-methyltransferase 3 beta in complex with a bis-tris molecule 2.04Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 E1891 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Mapped Variants
General Structure Information 3toj ASH2L structure of the spry domain of human ash2l 2.07Å AUTH Y.CHEN,F.CAO,B.WAN,Y.DOU,M.LEITITL STRUCTURE OF THE SPRY DOMAIN OF HUMAN ASH2L AND ITSTITL 2 INTERACTIONS WITH RBBP5 AND DPY30.REF CELL RES. V. 22 598 2012REFN ISSN 1001-0602PMID 22231628DOI 10.1038/CR.2012.9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ckk METTL1 crystal structure of human methyltransferase-like protein 1 1.55Å AUTH H.ZENG,A.DONG,E.DOBROVETSKY,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3db5 PRDM4 crystal structure of methyltransferase domain of human pr domain- containing protein 4 2.15Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 PR DOMAIN-CONTAINING PROTEIN 4.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tg5 SMYD2 structure of smyd2 in complex with p53 and sah 2.3Å AUTH L.WANG,L.LI,H.ZHANG,X.LUO,J.DAI,S.ZHOU,J.GU,J.ZHU,P.ATADJA,AUTH 2 C.LU,E.LI,K.ZHAOTITL STRUCTURE OF HUMAN SMYD2 REVEALS THE BASIS OF P53 TUMORTITL 2 SUPPRESSOR METHYLATIONREF J.BIOL.CHEM. 2011REFN ESSN 1083-351XPMID 21880715DOI 10.1074/JBC.M111.262410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants