3IEI.G | LCMT1

General Structure Information

PDB ID	3iei
HGNC Gene Label(s)	LCMT1
Structure Name	crystal structure of human leucine carboxylmethyltransferase-1 in complex with s-adenosyl homocysteine
Resolution	1.9Å
Reference	AUTH V.STANEVICH,L.JIANG,K.A.SATYSHUR,Y.LI,P.D.JEFFREY,Z.LI,AUTH 2 M.F.SEMMELHACK,Y.XINGTITL STRUCTURAL INSIGHTS INTO NOVEL FUNCTIONS OF A PRO-SURVIVALTITL 2 PP2A-SPECIFIC METHYLTRANSFERASEREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	310
Number Of SNVs	75
Number Of Permutations	30826
Optimal Distance Threshold	11.0
K Statistic	0.067
p-value	0.208

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
16:25123278		G>A	G:25	(-72.84, -6.21, 45.60)
16:25123287		G>D	G:28	(-74.99, -7.28, 41.22)
16:25123308		L>R	G:35	(-82.88, -8.21, 34.92)
16:25139812	rs371613496	G>S	G:44	(-91.34, -1.07, 24.42)
16:25139828		P>R	G:49	(-82.22, -6.77, 19.55)
16:25139830		Y>H	G:50	(-78.52, -6.78, 19.85)
16:25139857		K>E	G:59	(-91.07, -14.47, 35.25)
16:25139869		A>T	G:63	(-93.15, -0.13, 38.67)
16:25139878		I>V	G:66	(-88.87, 1.50, 37.66)
16:25143732		A>V	G:72	(-84.63, 8.40, 30.52)
16:25143737		V>I	G:74	(-81.13, 4.76, 27.86)
16:25143741	rs568052328	H>R	G:75	(-83.29, 9.25, 25.15)
16:25143746		V>I	G:77	(-76.87, 8.33, 27.74)
16:25143747		V>A	G:77	(-76.87, 8.33, 27.74)
16:25143749		S>C	G:78	(-78.10, 8.05, 23.49)
16:25143774		R>Q	G:86	(-74.32, 14.16, 15.74)
16:25143780		T>I	G:88	(-66.37, 13.59, 16.18)
16:25143790		H>Q	G:91	(-61.81, 10.54, 13.92)
16:25143791		C>R	G:92	(-63.92, 8.72, 18.07)
16:25143797		I>V	G:94	(-66.74, 5.29, 23.05)
16:25143800		V>I	G:95	(-64.57, 4.48, 27.27)
16:25143804	rs565452933	N>S	G:96	(-68.70, 2.15, 29.08)
16:25143809		G>R	G:98	(-69.10, -0.12, 33.90)
16:25151493		D>G	G:110	(-78.04, -1.38, 14.14)
16:25151507		P>S	G:115	(-66.51, 4.48, 16.91)
16:25151510		S>G	G:116	(-62.88, 4.54, 15.79)
16:25151525	rs377403554	V>I	G:121	(-64.37, -1.36, 31.69)
16:25151529		D>G	G:122	(-66.63, -4.35, 34.43)
16:25151534	rs370791605 COSM3888267	P>T	G:124	(-62.94, -9.51, 35.94)
16:25151537		M>V	G:125	(-67.16, -12.03, 37.59)
16:25151547		T>M	G:128	(-66.10, -13.87, 32.11)
16:25151560		H>Q	G:132	(-69.93, -17.66, 27.81)
16:25162913		H>R	G:148	(-61.44, -8.15, 13.42)
16:25162933		M>V	G:155	(-62.06, -13.80, 23.47)
16:25172426	rs368576981	G>E	G:157	(-59.78, -14.24, 29.39)
16:25172443	rs562196872	K>E	G:163	(-60.43, -2.82, 13.82)
16:25172453		A>V	G:166	(-63.08, -3.76, 23.56)
16:25172455	rs372670026	V>I	G:167	(-64.17, -6.19, 26.63)
16:25172474	rs58367253	R>Q	G:173	(-61.37, 0.12, 43.07)
16:25172482		S>T	G:176	(-52.15, 1.01, 36.54)
16:25172483	rs531215477	S>F	G:176	(-52.15, 1.01, 36.54)
16:25172506		K>E	G:184	(-52.18, -4.30, 26.55)
16:25175924		P>L	G:192	(-61.37, 12.49, 20.11)
16:25175926		T>A	G:193	(-62.31, 10.25, 24.15)
16:25175966		P>L	G:206	(-65.25, 9.88, 47.19)
16:25175999		A>V	G:217	(-58.52, 14.46, 32.08)
16:25176002		N>S	G:218	(-54.81, 14.05, 33.10)
16:25176004	rs199735451	S>G	G:219	(-55.45, 10.91, 29.46)
16:25176006	rs550609979	S>R	G:219	(-55.45, 10.91, 29.46)
16:25176008		F>Y	G:220	(-58.03, 11.43, 27.03)
16:25176012		E>D	G:221	(-55.85, 17.64, 24.19)
16:25176013		R>G	G:222	(-59.26, 16.24, 21.37)
16:25176034		E>Q	G:229	(-75.04, 9.07, 39.69)
16:25180449	rs200832194	R>L	G:236	(-88.29, 12.74, 54.53)
16:25180479	rs35016949	R>Q	G:246	(-76.94, 0.90, 53.73)
16:25180482		R>I	G:247	(-81.70, -3.22, 53.97)
16:25180484	rs376104801	R>C	G:248	(-80.13, -4.45, 47.55)
16:25180497		L>P	G:252	(-74.42, 4.19, 47.88)
16:25180500		A>V	G:253	(-69.66, 5.14, 48.88)
16:25180506		V>A	G:255	(-73.93, 9.27, 48.48)
16:25180520		S>A	G:260	(-76.42, 18.32, 44.44)
16:25182041	rs568089895	R>W	G:267	(-67.63, 14.42, 41.08)
16:25182051		S>L	G:270	(-62.44, 19.55, 40.84)
16:25182062		E>K	G:274	(-62.38, 22.76, 30.66)
16:25182068		A>T	G:276	(-70.31, 21.34, 33.77)
16:25182072		S>L	G:277	(-73.58, 20.12, 32.57)
16:25182080	rs369503396	D>N	G:280	(-83.44, 16.50, 37.04)
16:25182088		M>I	G:282	(-88.80, 15.06, 35.58)
16:25182096	rs372498836	Y>C	G:285	(-90.32, 12.33, 31.03)
16:25182099		N>S	G:286	(-90.62, 17.43, 31.43)
16:25182110	rs376933921	R>G	G:290	(-95.19, 17.69, 22.59)
16:25182111		R>Q	G:290	(-95.19, 17.69, 22.59)
16:25182114	rs370610552	A>G	G:291	(-94.87, 12.03, 21.11)
16:25182126		R>K	G:295	(-93.73, 5.50, 22.92)
16:25186278		L>P	G:302	(-98.49, 5.70, 36.45)
16:25186310		R>W	G:313	(-86.94, 16.09, 40.13)
16:25186311	rs180778942	R>Q	G:313	(-86.94, 16.09, 40.13)
16:25186352		L>F	G:327	(-64.80, 19.53, 17.97)
16:25189331		E>A	G:331	(-72.12, 23.90, 21.48)
16:25189337		T>I	G:333	(-77.39, 19.06, 24.74)