Assessment of Structural Intolerance and Durability
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vpp CLEC9A crystal structure of the human clec9a c-type lectin-like domain 1.64Å AUTH J.G.ZHANG,P.E.CZABOTAR,A.N.POLICHENI,I.CAMINSCHI,S.S.WAN,AUTH 2 S.KITSOULIS,K.M.TULLETT,A.Y.ROBIN,R.BRAMMANANTH,AUTH 3 M.F.VAN DELFT,J.LU,L.A.OREILLY,E.C.JOSEFSSON,B.T.KILE,AUTH 4 W.J.CHIN,J.D.MINTERN,M.A.OLSHINA,W.WONG,J.BAUM,M.D.WRIGHT,AUTH 5 D.C.HUANG,N.MOHANDAS,R.L.COPPEL,P.M.COLMAN,N.A.NICOLA,AUTH 6 K.SHORTMAN,M.H.LAHOUDTITL THE DENDRITIC CELL RECEPTOR CLEC9A BINDS DAMAGED CELLS VIATITL 2 EXPOSED ACTIN FILAMENTS.REF IMMUNITY V. 36 646 2012REFN ISSN 1074-7613PMID 22483802DOI 10.1016/J.IMMUNI.2012.03.009 Variant Set Distributions Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2khn ITSN1 nmr solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target hr3646e. -1.0Å AUTH J.L.MILLS,A.GHOSH,E.GARCIA,Q.ZHANG,R.SHASTRY,AUTH 2 E.L.FOOTE,H.JANJUA,T.B.ACTON,R.XIAO,J.K.EVERETT,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL NMR SOLUTION STRUCTURE OF THE EH 1 DOMAIN FROMTITL 2 HUMAN INTERSECTIN-1 PROTEIN. NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR3646E.REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 3ucr TIGIT crystal structure of the immunoreceptor tigit igv domain 2.63Å AUTH K.F.STENGEL,K.HARDEN-BOWLES,X.YU,L.ROUGE,J.YIN,AUTH 2 L.COMPS-AGRAR,C.WIESMANN,J.F.BAZAN,D.L.EATON,J.L.GROGANTITL STRUCTURE OF TIGIT IMMUNORECEPTOR BOUND TO POLIOVIRUSTITL 2 RECEPTOR REVEALS A CELL-CELL ADHESION AND SIGNALINGTITL 3 MECHANISM THAT REQUIRES CIS-TRANS RECEPTOR CLUSTERING.REF PROC.NATL.ACAD.SCI.USA V. 109 5399 2012REFN ISSN 0027-8424PMID 22421438DOI 10.1073/PNAS.1120606109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lp5 AGER crystal structure of the full-length human rage extracellular domain (vc1c2 fragment) 3.8Å AUTH L.YATIME,G.R.ANDERSENTITL STRUCTURAL INSIGHTS INTO THE OLIGOMERIZATION MODE OF THETITL 2 HUMAN RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS.REF FEBS J. V. 280 6556 2013REFN ISSN 1742-464XPMID 24119142DOI 10.1111/FEBS.12556 Variant Set Distributions Mapped Variants