Assessment of Structural Intolerance and Durability
General Structure Information 3h6n PLXND1 crystal structure of the ubiquitin-like domain of plexin d1 2.0Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,M.BUCK,H.PARKTITL CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OFTITL 2 PLEXIN D1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lop TMEM14A backbone structure of human membrane protein tmem14a -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2h16 ARL5A structure of human adp-ribosylation factor-like 5 (arl5) 2.0Å AUTH W.M.RABEH,W.TEMPEL,D.YANIW,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 5TITL 2 (ARL5)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jil GRIP1 crystal structure of 2nd pdz domain of glutamate receptor interacting protein-1 (grip1) 1.5Å AUTH J.TICKLE,J.ELKINS,A.C.W.PIKE,C.COOPER,E.SALAH,AUTH 2 E.PAPAGRIGORIOU,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,M.SUNDSTROM,D.DOYLETITL CRYSTAL STRUCTURE OF 2ND PDZ DOMAIN OF GLUTAMATE RECEPTORTITL 2 INTERACTING PROTEIN-1 (GRIP1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lom HIGD1A backbone structure of human membrane protein higd1a -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2v9r ROBO1 first and second ig domains from human robo1 (form 2) 2.0Å AUTH C.MORLOT,N.M.THIELENS,R.B.RAVELLI,W.HEMRIKA,R.A.ROMIJN,AUTH 2 P.GROS,S.CUSACK,A.A.MCCARTHYTITL STRUCTURAL INSIGHTS INTO THE SLIT-ROBO COMPLEX.REF PROC.NAT.ACAD.SCI.USA V. 104 14923 2007REFN ISSN 0027-8424PMID 17848514DOI 10.1073/PNAS.0705310104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4akm LAMP3 crystal structure of the human lysosome-associated membrane protein lamp-3 (aka dc-lamp) 2.69Å AUTH S.WILKE,J.KRAUSZE,K.BUSSOWTITL CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN OF THE DCTITL 2 LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN: IMPLICATIONS FOR THETITL 3 LYSOSOMAL GLYCOCALYX.REF BMC BIOL. V. 10 62 2012REFN ISSN 1741-7007PMID 22809326DOI 10.1186/1741-7007-10-62 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f37 TRPV2 crystal structure of the ankyrin repeat domain of human trpv2 1.7Å AUTH C.J.MCCLEVERTY,E.KOESEMA,A.PATAPOUTIAN,S.A.LESLEY,AUTH 2 A.KREUSCHTITL CRYSTAL STRUCTURE OF THE HUMAN TRPV2 CHANNELTITL 2 ANKYRIN REPEAT DOMAIN.REF PROTEIN SCI. V. 15 2201 2006REFN ISSN 0961-8368PMID 16882997DOI 10.1110/PS.062357206 Variant Set Distributions Mapped Variants