4CFF.A | PRKAA2

General Structure Information 4cff PRKAA2 structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) 3.92Å AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 Variant Set Distributions Ripley’s K Analysis Plots […]

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2YBX.A | PIP4K2A

General Structure Information 2ybx PIP4K2A crystal structure of human phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 2.56Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,S.GRASLUND,AUTH 3 T.KARLBERG,T.KOTENYOVA,E.KOUZNETSOVA,T.NYMAN,C.PERSSON,AUTH 4 H.SCHULER,M.I.SIPONEN,A.G.THORSELL,E.WAHLBERG,J.WEIGELT,AUTH 5 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHATIDYLINOSITOL-5-TITL 2 PHOSPHATE 4-KINASE TYPE-2 ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2W5A.A | NEK2

General Structure Information 2w5a NEK2 human nek2 kinase adp-bound 1.55Å AUTH I.WESTWOOD,D.M.CHEARY,J.E.BAXTER,M.W.RICHARDS,AUTH 2 R.L.VAN MONTFORT,A.M.FRY,R.BAYLISSTITL INSIGHTS INTO THE CONFORMATIONAL VARIABILITY ANDTITL 2 REGULATION OF HUMAN NEK2 KINASE.REF J.MOL.BIOL. V. 386 476 2009REFN ISSN 0022-2836PMID 19124027DOI 10.1016/J.JMB.2008.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4F7S.A | CDK8

General Structure Information 4f7s CDK8 crystal structure of human cdk8/cycc in the dmg-in conformation 2.2Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2EKX.A | BMX

General Structure Information 2ekx BMX solution structure of the human bmx sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN BMX SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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2R2P.A | EPHA5

General Structure Information 2r2p EPHA5 kinase domain of human ephrin type-a receptor 5 (epha5) 2.4Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3NR9.B | CLK2

General Structure Information 3nr9 CLK2 structure of human cdc2-like kinase 2 (clk2) 2.89Å AUTH A.CHAIKUAD,P.SAVITSKY,T.KROJER,J.R.C.MUNIZ,AUTH 2 P.FILIPPAKOPOULOS,P.RELLOS,T.KEATES,O.FEDOROV,A.C.W.PIKE,AUTH 3 J.ESWARAN,G.BERRIDGE,C.PHILLIPS,Y.ZHANG,F.VON DELFT,AUTH 4 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3GUB.A | DAPK1

General Structure Information 3gub DAPK1 crystal structure of dapkl93g complexed with n6-(2- phenylethyl)adenosine 1.71Å AUTH L.K.MCNAMARA,J.S.SCHAVOCKY,D.M.WATTERSON,AUTH 2 J.S.BRUNZELLETITL CRYSTAL STRUCTURES OF THE DAPK GATEKEEPER MUTANTTITL 2 COMPLEXED WITH N6-MODIFIED ADENOSINE ANALOGS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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1UA2.D | CDK7

General Structure Information 1ua2 CDK7 crystal structure of human cdk7 3.02Å AUTH G.LOLLI,E.D.LOWE,N.R.BROWN,L.N.JOHNSONTITL THE CRYSTAL STRUCTURE OF HUMAN CDK7 AND ITS PROTEINTITL 2 RECOGNITION PROPERTIESREF STRUCTURE V. 12 2067 2004REFN ISSN 0969-2126PMID 15530371DOI 10.1016/J.STR.2004.08.013 Variant Set Distributions Mapped Variants

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2E7H.A | EPHB4

General Structure Information 2e7h EPHB4 solution structure of the second fn3 domain from human ephrin type-b receptor 4 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN FROMTITL 2 HUMAN EPHRIN TYPE-B RECEPTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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