Assessment of Structural Intolerance and Durability
General Structure Information 2eho GINS2 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 2vwf GAB2 grb2 sh3c (2) 1.58Å AUTH M.HARKIOLAKI,T.TSIRKA,M.LEWITZKY,P.C.SIMISTER,AUTH 2 D.JOSHI,L.E.BIRD,E.Y.JONES,N.OREILLY,S.M.FELLERTITL DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2TITL 2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2.REF STRUCTURE V. 17 809 2009REFN ISSN 0969-2126PMID 19523899DOI 10.1016/J.STR.2009.03.017 Variant Set Distributions Mapped Variants
General Structure Information 4hxi KLHL3 crystal structure of klhl3/cul3 complex 3.51Å AUTH A.X.JI,G.G.PRIVETITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF KLHL3/CUL3TITL 2 COMPLEX AND IMPLICATIONS OF FHHT MUTATIONS IN CUL3 BINDINGREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l5y STIM2 nmr structure of calcium-loaded stim2 ef-sam. -1.0Å AUTH L.ZHENG,P.B.STATHOPULOS,R.SCHINDL,G.Y.LI,C.ROMANIN,M.IKURATITL AUTO-INHIBITORY ROLE OF THE EF-SAM DOMAIN OF STIM PROTEINSTITL 2 IN STORE-OPERATED CALCIUM ENTRY.REF PROC.NATL.ACAD.SCI.USA V. 108 1337 2011REFN ISSN 0027-8424PMID 21217057DOI 10.1073/PNAS.1015125108 Variant Set Distributions Mapped Variants
General Structure Information 3au5 MYO10 structure of the human myosin-x myth4-ferm cassette 2.55Å AUTH Y.HIRANO,T.HATANO,A.TAKAHASHI,M.TORIYAMA,N.INAGAKI,AUTH 2 T.HAKOSHIMATITL STRUCTURAL BASIS OF CARGO RECOGNITION BY THE MYOSIN-XTITL 2 MYTH4-FERM DOMAINREF EMBO J. V. 30 2734 2011REFN ISSN 0261-4189PMID 21642953DOI 10.1038/EMBOJ.2011.177 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 3v4j APOBEC3G first-in-class small molecule inhibitors of the single-strand dna cytosine deaminase apobec3g 2.04Å AUTH M.LI,S.M.SHANDILYA,M.A.CARPENTER,A.RATHORE,W.L.BROWN,AUTH 2 A.L.PERKINS,D.A.HARKI,J.SOLBERG,D.J.HOOK,K.K.PANDEY,AUTH 3 M.A.PARNIAK,J.R.JOHNSON,N.J.KROGAN,M.SOMASUNDARAN,A.ALI,AUTH 4 C.A.SCHIFFER,R.S.HARRISTITL FIRST-IN-CLASS SMALL MOLECULE INHIBITORS OF THETITL 2 SINGLE-STRAND DNA CYTOSINE DEAMINASE APOBEC3G.REF ACS CHEM.BIOL. V. 7 506 2012REFN ISSN 1554-8929PMID 22181350DOI 10.1021/CB200440Y Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3vow APOBEC3C crystal structure of the human apobec3c having hiv-1 vif-binding interface 2.15Å AUTH S.KITAMURA,H.ODE,M.NAKASHIMA,M.IMAHASHI,Y.NAGANAWA,AUTH 2 T.KUROSAWA,Y.YOKOMAKU,T.YAMANE,N.WATANABE,A.SUZUKI,AUTH 3 W.SUGIURA,Y.IWATANITITL THE APOBEC3C CRYSTAL STRUCTURE AND THE INTERFACE FOR HIV-1TITL 2 VIF BINDING.REF NAT.STRUCT.MOL.BIOL. V. 19 1005 2012REFN ISSN 1545-9993PMID 23001005DOI 10.1038/NSMB.2378 Variant Set Distributions Mapped Variants
General Structure Information 3ux3 FAM96A crystal structure of domain-swapped fam96a minor dimer 1.8Å AUTH K.-E.CHEN,A.A.RICHARDS,J.K.ARIFFIN,I.L.ROSS,M.J.SWEET,AUTH 2 S.KELLIE,B.KOBE,J.L.MARTINTITL THE MAMMALIAN DUF59 PROTEIN FAM96A FORMS TWO DISTINCT TYPESTITL 2 OF DOMAIN-SWAPPED DIMERREF ACTA CRYSTALLOGR.,SECT.D V. 68 637 2012REFN ISSN 0907-4449DOI 10.1107/S0907444912006592 Variant Set Distributions Mapped Variants
General Structure Information 4nxt MIEF1 crystal structure of the cytosolic domain of human mid51 2.12Å AUTH V.RICHTER,C.S.PALMER,L.D.OSELLAME,A.P.SINGH,K.ELGASS,AUTH 2 D.A.STROUD,H.SESAKI,M.KVANSAKUL,M.T.RYANTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF MID51, A DYNAMINTITL 2 RECEPTOR REQUIRED FOR MITOCHONDRIAL FISSION.REF J.CELL BIOL. V. 204 477 2014REFN ISSN 0021-9525PMID 24515348DOI 10.1083/JCB.201311014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]