Assessment of Structural Intolerance and Durability
General Structure Information 2kk0 ARID3A solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (nesg) target hr4394c -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE ARID DOMAIN OF HUMAN AT-RICHTITL 2 INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A: A HUMAN CANCERTITL 3 PROTEIN INTERACTION NETWORK TARGET.REF PROTEINS V. […]
General Structure Information 4fqn CCM2 crystal structure of the ccm2 c-terminal harmonin homology domain (hhd) 1.9Å AUTH O.S.FISHER,R.ZHANG,X.LI,J.W.MURPHY,B.DEMELER,T.J.BOGGONTITL STRUCTURAL STUDIES OF CEREBRAL CAVERNOUS MALFORMATIONS 2TITL 2 (CCM2) REVEAL A FOLDED HELICAL DOMAIN AT ITS C-TERMINUS.REF FEBS LETT. V. 587 272 2013REFN ISSN 0014-5793PMID 23266514DOI 10.1016/J.FEBSLET.2012.12.011 Variant Set Distributions Mapped Variants
General Structure Information 4ewi NLRP4 crystal structure of the nlrp4 pyrin domain 2.28Å AUTH C.EIBL,S.GRIGORIU,M.HESSENBERGER,J.WENGER,S.PUEHRINGER,AUTH 2 A.S.PINHEIRO,R.N.WAGNER,M.PROELL,J.C.REED,R.PAGE,AUTH 3 K.DIEDERICHS,W.PETITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE NLRP4 PYRINTITL 2 DOMAIN.REF BIOCHEMISTRY V. 51 7330 2012REFN ISSN 0006-2960PMID 22928810DOI 10.1021/BI3007059 Variant Set Distributions Mapped Variants
General Structure Information 2y9q MKNK1 crystal structure of human erk2 complexed with a mapk docking peptide 1.55Å AUTH A.GARAI,A.ZEKE,G.GOGL,I.TORO,F.FORDOS,H.BLANKENBURG,AUTH 2 T.BARKAI,J.VARGA,A.ALEXA,D.EMIG,M.ALBRECHT,A.REMENYITITL SPECIFICITY OF LINEAR MOTIFS THAT BIND TO A COMMON MITOGEN-TITL 2 ACTIVATED PROTEIN KINASE DOCKING GROOVE.REF SCI. SIGNAL V. 5 74 2012REFN ESSN 1937-9145PMID 23047924DOI 10.1126/SCISIGNAL.2003004 Variant Set Distributions Mapped Variants
General Structure Information 3iv1 TSG101 coiled-coil domain of tumor susceptibility gene 101 2.5Å AUTH D.NECULAI,G.V.AVVAKUMOV,A.K.WERNIMONT,S.XUE,AUTH 2 J.R.WALKER,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL COILED-COIL DOMAIN OF HUMAN TSG101REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kje CREBBP nmr structure of cbp taz2 and adenoviral e1a complex -1.0Å AUTH J.C.FERREON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR SUBVERSION OF CELLULAR CONTROLTITL 2 MECHANISMS BY THE ADENOVIRAL E1A ONCOPROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13260 2009REFN ISSN 0027-8424PMID 19651603DOI 10.1073/PNAS.0906770106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2xnk TOPBP1 structure and function of the rad9-binding region of the dna damage checkpoint adaptor topbp1 2.6Å AUTH M.RAPPAS,A.W.OLIVER,L.H.PEARLTITL STRUCTURE AND FUNCTION OF THE RAD9-BINDING REGION OF THETITL 2 DNA-DAMAGE CHECKPOINT ADAPTOR TOPBP1.REF NUCLEIC ACIDS RES. V. 39 313 2011REFN ISSN 0305-1048PMID 20724438DOI 10.1093/NAR/GKQ743 Variant Set Distributions Mapped Variants
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 2r02 PDCD6IP crystal structure of alix/aip1 in complex with the hiv-1 ypltsl late domain 2.6Å AUTH Q.ZHAI,R.D.FISHER,H.Y.CHUNG,D.G.MYSZKA,AUTH 2 W.I.SUNDQUIST,C.P.HILLTITL STRUCTURAL AND FUNCTIONAL STUDIES OF ALIXTITL 2 INTERACTIONS WITH YPX(N)L LATE DOMAINS OF HIV-1TITL 3 AND EIAV.REF NAT.STRUCT.MOL.BIOL. V. 15 43 2008REFN ISSN 1545-9993PMID 18066081DOI 10.1038/NSMB1319 Variant Set Distributions Ripley’s K Analysis Plots […]