General Structure Information
| PDB ID | 3v4j |
| HGNC Gene Label(s) | APOBEC3G |
| Structure Name | first-in-class small molecule inhibitors of the single-strand dna cytosine deaminase apobec3g |
| Resolution | 2.04Å |
| Reference | AUTH M.LI,S.M.SHANDILYA,M.A.CARPENTER,A.RATHORE,W.L.BROWN,AUTH 2 A.L.PERKINS,D.A.HARKI,J.SOLBERG,D.J.HOOK,K.K.PANDEY,AUTH 3 M.A.PARNIAK,J.R.JOHNSON,N.J.KROGAN,M.SOMASUNDARAN,A.ALI,AUTH 4 C.A.SCHIFFER,R.S.HARRISTITL FIRST-IN-CLASS SMALL MOLECULE INHIBITORS OF THETITL 2 SINGLE-STRAND DNA CYTOSINE DEAMINASE APOBEC3G.REF ACS CHEM.BIOL. V. 7 506 2012REFN ISSN 1554-8929PMID 22181350DOI 10.1021/CB200440Y |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 185 |
| Number Of SNVs | 61 |
| Number Of Permutations | 6564 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.223 |
| p-value | 0.546 |
COSMIC
| Number Of Residues | 185 |
| Number Of SNVs | 3 |
| Number Of Permutations | 107 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.333 |
| p-value | 0.757 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.513 |
| p-value | 0.315 |