Assessment of Structural Intolerance and Durability
General Structure Information 4ewi NLRP4 crystal structure of the nlrp4 pyrin domain 2.28Å AUTH C.EIBL,S.GRIGORIU,M.HESSENBERGER,J.WENGER,S.PUEHRINGER,AUTH 2 A.S.PINHEIRO,R.N.WAGNER,M.PROELL,J.C.REED,R.PAGE,AUTH 3 K.DIEDERICHS,W.PETITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE NLRP4 PYRINTITL 2 DOMAIN.REF BIOCHEMISTRY V. 51 7330 2012REFN ISSN 0006-2960PMID 22928810DOI 10.1021/BI3007059 Variant Set Distributions Mapped Variants
General Structure Information 4dwn C9orf89 crystal structure of human bincard card 1.58Å AUTH K.E.CHEN,A.A.RICHARDS,T.T.CARADOC-DAVIES,P.R.VAJJHALA,AUTH 2 G.ROBIN,L.H.LUA,J.M.HILL,K.SCHRODER,M.J.SWEET,S.KELLIE,AUTH 3 B.KOBE,J.MARTINTITL THE STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN OF BINCARDTITL 2 REVEALS THAT ALL THREE CYSTEINES CAN BE OXIDIZED.REF ACTA CRYSTALLOGR.,SECT.D V. 69 774 2013REFN ISSN 0907-4449PMID 23633586DOI 10.1107/S0907444913001558 Variant Set Distributions Mapped Variants
General Structure Information 4ifp NLRP1 x-ray crystal structure of human nlrp1 card domain 1.99Å AUTH T.JIN,J.CURRY,P.SMITH,J.JIANG,T.S.XIAOTITL STRUCTURE OF THE NLRP1 CASPASE RECRUITMENT DOMAIN SUGGESTSTITL 2 POTENTIAL MECHANISMS FOR ITS ASSOCIATION WITH PROCASPASE-1.REF PROTEINS V. 81 1266 2013REFN ISSN 0887-3585PMID 23508996DOI 10.1002/PROT.24287 Variant Set Distributions Mapped Variants
General Structure Information 3d34 SPON2 structure of the f-spondin domain of mindin 1.8Å AUTH Y.LI,C.CAO,W.JIA,L.YU,M.MO,Q.WANG,Y.HUANG,J.M.LIM,AUTH 2 M.ISHIHARA,L.WELLS,P.AZADI,H.ROBINSON,Y.W.HE,AUTH 3 L.ZHANG,R.A.MARIUZZATITL STRUCTURE OF THE F-SPONDIN DOMAIN OF MINDIN, ANTITL 2 INTEGRIN LIGAND AND PATTERN RECOGNITION MOLECULE.REF EMBO J. V. 28 286 2009REFN ISSN 0261-4189PMID 19153605DOI 10.1038/EMBOJ.2008.288 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2j67 TLR10 the tir domain of human toll-like receptor 10 (tlr10) 2.2Å AUTH T.NYMAN,P.STENMARK,S.FLODIN,I.JOHANSSON,M.HAMMARSTROM,AUTH 2 P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF THE HUMAN TOLL-LIKE RECEPTOR 10TITL 2 CYTOPLASMIC DOMAIN REVEALS A PUTATIVE SIGNALING DIMER.REF J.BIOL.CHEM. V. 283 11861 2008REFN ISSN 0021-9258PMID 18332149DOI 10.1074/JBC.C800001200 Variant Set Distributions Mapped Variants
General Structure Information 2km6 NLRP7 nmr structure of the nlrp7 pyrin domain -1.0Å AUTH A.S.PINHEIRO,M.PROELL,C.EIBL,R.PAGE,R.SCHWARZENBACHER,W.PETITITL THREE-DIMENSIONAL STRUCTURE OF THE NLRP7 PYRIN DOMAIN:TITL 2 INSIGHT INTO PYRIN-PYRIN-MEDIATED EFFECTOR DOMAIN SIGNALINGTITL 3 IN INNATE IMMUNITY.REF J.BIOL.CHEM. V. 285 27402 2010REFN ISSN 0021-9258PMID 20547486DOI 10.1074/JBC.M110.113191 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2w4r DHX58 crystal structure of the regulatory domain of human lgp2 2.6Å AUTH D.A.PIPPIG,J.C.HELLMUTH,S.CUI,A.KIRCHHOFER,AUTH 2 K.LAMMENS,A.LAMMENS,A.SCHMIDT,S.ROTHENFUSSER,AUTH 3 K.P.HOPFNERTITL THE REGULATORY DOMAIN OF THE RIG-I FAMILY ATPASETITL 2 LGP2 SENSES DOUBLE-STRANDED RNA.REF NUCLEIC ACIDS RES. V. 37 2014 2009REFN ISSN 0305-1048PMID 19208642DOI 10.1093/NAR/GKP059 Variant Set Distributions Mapped Variants
General Structure Information 1twq PGLYRP3 crystal structure of the c-terminal pgn-binding domain of human pgrp- ialpha in complex with pgn analog muramyl tripeptide 2.3Å AUTH R.GUAN,A.ROYCHOWDHURY,B.EMBER,S.KUMAR,G.-A.BOONS,AUTH 2 R.A.MARIUZZATITL STRUCTURAL BASIS FOR PEPTIDOGLYCAN BINDING BY PEPTIDOGLYCANTITL 2 RECOGNITION PROTEINSREF PROC.NATL.ACAD.SCI.USA V. 101 17168 2004REFN ISSN 0027-8424PMID 15572450DOI 10.1073/PNAS.0407856101 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2if7 SLAMF6 crystal structure of ntb-a 3.0Å AUTH E.CAO,U.A.RAMAGOPAL,A.FEDOROV,E.FEDOROV,Q.YAN,J.W.LARY,AUTH 2 J.L.COLE,S.G.NATHENSON,S.C.ALMOTITL NTB-A RECEPTOR CRYSTAL STRUCTURE: INSIGHTS INTO HOMOPHILICTITL 2 INTERACTIONS IN THE SIGNALING LYMPHOCYTIC ACTIVATIONTITL 3 MOLECULE RECEPTOR FAMILY.REF IMMUNITY V. 25 559 2006REFN ISSN 1074-7613PMID 17045824DOI 10.1016/J.IMMUNI.2006.06.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3whd CLEC4D c-type lectin, human mcl 2.29Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants