General Structure Information
| PDB ID | 1twq |
| HGNC Gene Label(s) | PGLYRP3 |
| Structure Name | crystal structure of the c-terminal pgn-binding domain of human pgrp- ialpha in complex with pgn analog muramyl tripeptide |
| Resolution | 2.3Å |
| Reference | AUTH R.GUAN,A.ROYCHOWDHURY,B.EMBER,S.KUMAR,G.-A.BOONS,AUTH 2 R.A.MARIUZZATITL STRUCTURAL BASIS FOR PEPTIDOGLYCAN BINDING BY PEPTIDOGLYCANTITL 2 RECOGNITION PROTEINSREF PROC.NATL.ACAD.SCI.USA V. 101 17168 2004REFN ISSN 0027-8424PMID 15572450DOI 10.1073/PNAS.0407856101 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 165 |
| Number Of SNVs | 43 |
| Number Of Permutations | 2483 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.054 |
| p-value | 0.384 |
COSMIC
| Number Of Residues | 165 |
| Number Of SNVs | 3 |
| Number Of Permutations | 141 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.667 |
| p-value | 0.721 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.23 |
| p-value | 0.489 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
