Assessment of Structural Intolerance and Durability
General Structure Information 4hsa IL17RA structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 3un9 NLRX1 crystal structure of an immune receptor 2.65Å AUTH M.HONG,S.I.YOON,I.A.WILSONTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE RNA-BINDINGTITL 2 ELEMENT OF THE NLRX1 INNATE IMMUNE MODULATOR.REF IMMUNITY V. 36 337 2012REFN ISSN 1074-7613PMID 22386589DOI 10.1016/J.IMMUNI.2011.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nms CD300LF the crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells irem-1 2.6Å AUTH J.A.MARQUEZ,E.GALFRE,F.DUPEUX,D.FLOT,O.MORAN,AUTH 2 N.DIMASITITL THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAINTITL 2 OF THE INHIBITOR RECEPTOR EXPRESSED ON MYELOIDTITL 3 CELLS IREM-1.REF J.MOL.BIOL. V. 367 310 2007REFN ISSN 0022-2836PMID 17275839DOI 10.1016/J.JMB.2007.01.011 Variant Set […]
General Structure Information 2m1x TICAM1 ticam-1 tir domain structure -1.0Å AUTH Y.ENOKIZONO,H.KUMETA,K.FUNAMI,M.HORIUCHI,J.SARMIENTO,AUTH 2 K.YAMASHITA,D.M.STANDLEY,M.MATSUMOTO,T.SEYA,F.INAGAKITITL STRUCTURES AND INTERFACE MAPPING OF THE TIRTITL 2 DOMAIN-CONTAINING ADAPTOR MOLECULES INVOLVED IN INTERFERONTITL 3 SIGNALING.REF PROC.NATL.ACAD.SCI.USA V. 110 19908 2013REFN ISSN 0027-8424PMID 24255114DOI 10.1073/PNAS.1222811110 Variant Set Distributions Mapped Variants
General Structure Information 4hwn FCRLA crystal structure of the second ig-c2 domain of human fc-receptor like a (fcrla), isoform 9 [nysgrc-005836] 2.01Å AUTH P.R.KUMAR,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE SECOND IG-C2 DOMAIN OF THE HUMANTITL 2 FC-RECEPTOR LIKE A, ISOFORM 9 [NYSGRC-005836]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2frg TREML1 structure of the immunoglobulin-like domain of human tlt-1 1.19Å AUTH J.L.GATTIS,A.V.WASHINGTON,M.M.CHISHOLM,L.QUIGLEY,AUTH 2 A.SZYK,D.W.MCVICAR,J.LUBKOWSKITITL THE STRUCTURE OF THE EXTRACELLULAR DOMAIN OFTITL 2 TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLSTITL 3 LIKE TRANSCRIPT-1 AND EVIDENCE FOR A NATURALLYTITL 4 OCCURRING SOLUBLE FRAGMENT.REF J.BIOL.CHEM. V. 281 13396 2006REFN ISSN 0021-9258PMID 16505478DOI 10.1074/JBC.M600489200 Variant Set […]
General Structure Information 3wbp CLEC4C crystal structure of carbohydrate recognition domain of blood dendritic cell antigen-2 (bdca2) lectin (crystal form-1) 1.8Å AUTH M.NAGAE,A.IKEDA,Y.KITAGO,N.MATSUMOTO,K.YAMAMOTO,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF CARBOHYDRATE RECOGNITION DOMAIN OFTITL 2 BLOOD DENDRITIC CELL ANTIGEN-2 (BDCA2) REVEAL A COMMONTITL 3 DOMAIN-SWAPPED DIMERREF PROTEINS 2013REFN ESSN 1097-0134PMID 24425442DOI 10.1002/PROT.24504 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2x5y ZC3HAV1 human zc3hav1 (artd13), c-terminal domain 1.05Å AUTH T.KARLBERG,M.KLEPSCH,A.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASETITL 2 ACTIVITY IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGERTITL 3 ANTIVIRAL PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cry KIRREL3 solution structure of the fifth ig-like domain of human kin of irre like 3 -1.0Å AUTH C.KUROSAKI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH IG-LIKE DOMAIN OFTITL 2 HUMAN KIN OF IRRE LIKE 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4emu TMEM173 crystal structure of ligand free human sting 1.9Å AUTH C.SHU,G.YI,T.WATTS,C.C.KAO,P.LITITL STRUCTURE OF STING BOUND TO CYCLIC DI-GMP REVEALS THETITL 2 MECHANISM OF CYCLIC DINUCLEOTIDE RECOGNITION BY THE IMMUNETITL 3 SYSTEM.REF NAT.STRUCT.MOL.BIOL. V. 19 722 2012REFN ISSN 1545-9993PMID 22728658DOI 10.1038/NSMB.2331 Variant Set Distributions Mapped Variants