Assessment of Structural Intolerance and Durability
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1nbq F11R crystal structure of human junctional adhesion molecule type 1 2.9Å AUTH A.E.PROTA,J.A.CAMPBELL,P.SCHELLING,J.C.FORREST,AUTH 2 M.J.WATSON,T.R.PETERS,M.AURRAND-LIONS,B.A.IMHOF,AUTH 3 T.S.DERMODY,T.STEHLETITL CRYSTAL STRUCTURE OF HUMAN JUNCTIONAL ADHESIONTITL 2 MOLECULE 1: IMPLICATIONS FOR REOVIRUS BINDINGREF PROC.NATL.ACAD.SCI.USA V. 100 5366 2003REFN ISSN 0027-8424PMID 12697893DOI 10.1073/PNAS.0937718100 Variant Set Distributions Mapped Variants
General Structure Information 2ice VSIG4 crig bound to c3c 3.1Å AUTH C.WIESMANN,K.J.KATSCHKE,J.YIN,K.Y.HELMY,M.STEFFEK,AUTH 2 W.J.FAIRBROTHER,S.A.MCCALLUM,L.EMBUSCADO,L.DEFORGE,P.E.HASS,AUTH 3 M.VAN LOOKEREN CAMPAGNETITL STRUCTURE OF C3B IN COMPLEX WITH CRIG GIVES INSIGHTS INTOTITL 2 REGULATION OF COMPLEMENT ACTIVATION.REF NATURE V. 444 217 2006REFN ISSN 0028-0836PMID 17051150DOI 10.1038/NATURE05263 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3bin EPB41L3 structure of the dal-1 and tslc1 (372-383) complex 2.3Å AUTH R.D.BUSAM,A.-G.THORSELL,A.FLORES,M.HAMMARSTROM,C.PERSSON,AUTH 2 B.OBRINK,B.M.HALLBERGTITL STRUCTURAL BASIS OF TUMOR SUPPRESSOR IN LUNG CANCER 1TITL 2 (TSLC1) BINDING TO DIFFERENTIALLY EXPRESSED INTITL 3 ADENOCARCINOMA OF THE LUNG (DAL-1/4.1B)REF J.BIOL.CHEM. V. 286 4511 2011REFN ISSN 0021-9258PMID 21131357DOI 10.1074/JBC.M110.174011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3bn3 ICAM5 crystal structure of icam-5 in complex with al i domain 2.1Å AUTH H.ZHANG,J.M.CASASNOVAS,M.JIN,J.H.LIU,C.G.GAHMBERG,AUTH 2 T.A.SPRINGER,J.-H.WANGTITL AN UNUSUAL ALLOSTERIC MOBILITY OF THE C-TERMINAL HELIX OF ATITL 2 HIGH-AFFINITY ALPHA L INTEGRIN I DOMAIN VARIANT BOUND TOTITL 3 ICAM-5REF MOL.CELL V. 31 432 2008REFN ISSN 1097-2765PMID 18691975DOI 10.1016/J.MOLCEL.2008.06.022 Variant Set Distributions Mapped […]
General Structure Information 2box EMR2 egf domains 1,2,5 of human emr2, a 7-tm immune system molecule, in complex with strontium. 2.5Å AUTH R.J.M.ABBOTT,I.SPENDLOVE,P.ROVERSI,H.FITZGIBBON,V.KNOTT,AUTH 2 P.TERIETE,J.M.MCDONNELL,P.A.HANDFORD,S.M.LEATITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A NOVEL TTITL 2 CELL RECEPTOR CO-REGULATORY PROTEIN COMPLEX, CD97-CD55.REF J.BIOL.CHEM. V. 282 22023 2007REFN ISSN 0021-9258PMID 17449467DOI 10.1074/JBC.M702588200 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3fn3 CD274 dimeric structure of pd-l1 2.7Å AUTH Y.CHEN,P.LIU,F.GAO,H.CHENG,J.QI,G.F.GAOTITL A DIMERIC STRUCTURE OF PD-L1: FUNCTIONAL UNITS ORTITL 2 EVOLUTIONARY RELICS?REF PROTEIN CELL V. 1 153 2010REFN ISSN 1674-800XPMID 21203985DOI 10.1007/S13238-010-0022-1 Variant Set Distributions Mapped Variants
General Structure Information 3kqg CD207 trimeric structure of langerin 2.3Å AUTH H.FEINBERG,A.S.POWLESLAND,M.E.TAYLOR,W.I.WEISTITL TRIMERIC STRUCTURE OF LANGERIN.REF J.BIOL.CHEM. V. 285 13285 2010REFN ISSN 0021-9258PMID 20181944DOI 10.1074/JBC.M109.086058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4i2x SIRPG crystal structure of signal regulatory protein gamma (sirp-gamma) in complex with fabox117 2.48Å AUTH J.E.NETTLESHIP,J.REN,D.J.SCOTT,N.RAHMAN,D.HATHERLEY,Y.ZHAO,AUTH 2 D.I.STUART,A.N.BARCLAY,R.J.OWENSTITL CRYSTAL STRUCTURE OF SIGNAL REGULATORY PROTEIN GAMMA (SIRPTITL 2 GAMMA) IN COMPLEX WITH AN ANTIBODY FAB FRAGMENT.REF BMC STRUCT.BIOL. V. 13 13 2013REFN ESSN 1472-6807PMID 23826770DOI 10.1186/1472-6807-13-13 Variant Set Distributions Ripley’s K Analysis […]