General Structure Information
| PDB ID | 2box |
| HGNC Gene Label(s) | EMR2 |
| Structure Name | egf domains 1,2,5 of human emr2, a 7-tm immune system molecule, in complex with strontium. |
| Resolution | 2.5Å |
| Reference | AUTH R.J.M.ABBOTT,I.SPENDLOVE,P.ROVERSI,H.FITZGIBBON,V.KNOTT,AUTH 2 P.TERIETE,J.M.MCDONNELL,P.A.HANDFORD,S.M.LEATITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A NOVEL TTITL 2 CELL RECEPTOR CO-REGULATORY PROTEIN COMPLEX, CD97-CD55.REF J.BIOL.CHEM. V. 282 22023 2007REFN ISSN 0021-9258PMID 17449467DOI 10.1074/JBC.M702588200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 135 |
| Number Of SNVs | 28 |
| Number Of Permutations | 20888 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.474 |
| p-value | 0.006 |
COSMIC
| Number Of Residues | 135 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.675 |
| p-value | 0.158 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
