2J67.A | TLR10

General Structure Information

PDB ID	2j67
HGNC Gene Label(s)	TLR10
Structure Name	the tir domain of human toll-like receptor 10 (tlr10)
Resolution	2.2Å
Reference	AUTH T.NYMAN,P.STENMARK,S.FLODIN,I.JOHANSSON,M.HAMMARSTROM,AUTH 2 P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF THE HUMAN TOLL-LIKE RECEPTOR 10TITL 2 CYTOPLASMIC DOMAIN REVEALS A PUTATIVE SIGNALING DIMER.REF J.BIOL.CHEM. V. 283 11861 2008REFN ISSN 0021-9258PMID 18332149DOI 10.1074/JBC.C800001200

Variant Set Distributions

ExAC Variants

Number Of Residues	141
Number Of SNVs	40
Number Of Permutations	11360
Optimal Distance Threshold	13.0
K Statistic	0.214
p-value	0.716

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
4:38775323	COSM1055117	R>K	A:630	(40.84, 15.39, 64.74)
4:38775320		N>S	A:631	(42.72, 20.26, 66.66)
4:38775314		R>Q	A:633	(46.03, 25.19, 65.41)
4:38775306	COSM4124527	A>T	A:636	(46.36, 26.47, 54.49)
4:38775299	rs369336701	I>T	A:638	(51.69, 26.08, 51.35)
4:38775284		H>R	A:643	(64.80, 25.89, 44.56)
4:38775281		D>V	A:644	(59.45, 26.88, 43.70)
4:38775273		W>R	A:647	(53.89, 30.50, 42.54)
4:38775270		V>M	A:648	(54.83, 30.61, 46.98)
4:38775261		E>K	A:651	(51.99, 35.18, 42.42)
4:38775227		S>F	A:662	(41.91, 36.39, 57.95)
4:38775213	rs375772822	L>F	A:667	(54.42, 27.88, 55.99)
4:38775155	rs143358634	I>T	A:686	(48.27, 17.63, 56.37)
4:38775143		Y>C	A:690	(39.37, 22.90, 54.87)
4:38775140		K>R	A:691	(42.31, 22.54, 51.90)
4:38775124	rs149212123	L>F	A:696	(53.80, 19.65, 42.00)
4:38775119		P>L	A:698	(60.95, 19.07, 39.02)
4:38775078	rs369713541	F>L	A:712	(50.18, 11.09, 50.75)
4:38775072		H>N	A:714	(49.52, 4.18, 54.40)
4:38775039	rs375536529	I>V	A:725	(44.86, 17.29, 48.84)
4:38775029	rs144520113	I>T	A:728	(49.54, 23.36, 41.94)
4:38775015	rs553174801	I>F	A:733	(56.86, 16.45, 36.26)
4:38775011	COSM3603505	P>Q	A:734	(59.53, 14.56, 33.56)
4:38775005	rs11466660	Y>C	A:736	(61.74, 11.02, 31.76)
4:38774997		P>S	A:739	(60.71, 8.10, 41.53)
4:38774973		A>P	A:747	(48.58, 8.63, 38.89)
4:38774963		E>G	A:750	(48.07, 9.53, 33.70)
4:38774957	rs149895872	K>R	A:752	(46.15, 15.43, 33.39)
4:38774943		W>G	A:757	(51.24, 29.40, 36.72)
4:38774934	rs371911164	D>N	A:760	(49.81, 32.56, 28.84)
4:38774930	rs139111585	R>K	A:761	(51.24, 37.67, 31.29)
4:38774927	rs529846468	R>H	A:762	(47.59, 35.77, 27.81)
4:38774928	rs144922246	R>C	A:762	(47.59, 35.77, 27.81)
4:38774921		C>Y	A:764	(46.55, 33.76, 35.17)
4:38774915		L>P	A:766	(41.07, 30.44, 34.29)
4:38774912		F>C	A:767	(45.58, 29.23, 38.34)
4:38774906		A>E	A:769	(39.46, 30.87, 39.54)
4:38774907		A>T	A:769	(39.46, 30.87, 39.54)
4:38774901		L>F	A:771	(42.87, 28.00, 43.46)
4:38774897		R>Q	A:772	(37.73, 31.19, 43.09)
4:38774889	rs4129009	I>V	A:775	(40.19, 26.59, 48.13)
4:38774886		N>D	A:776	(35.64, 27.68, 48.89)