Assessment of Structural Intolerance and Durability
General Structure Information 2xwj C3 crystal structure of complement c3b in complex with factor b 4.0Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3p23 ERN1 crystal structure of the human kinase and rnase domains in complex with adp 2.7Å AUTH M.M.ALI,T.BAGRATUNI,E.L.DAVENPORT,P.R.NOWAK,AUTH 2 M.C.SILVA-SANTISTEBAN,A.HARDCASTLE,C.MCANDREWS,M.G.ROWLANDS,AUTH 3 G.J.MORGAN,W.AHERNE,I.COLLINS,F.E.DAVIES,L.H.PEARLTITL STRUCTURE OF THE IRE1 AUTOPHOSPHORYLATION COMPLEX ANDTITL 2 IMPLICATIONS FOR THE UNFOLDED PROTEIN RESPONSE.REF EMBO J. V. 30 894 2011REFN ISSN 0261-4189PMID 21317875DOI 10.1038/EMBOJ.2011.18 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1ohc CDC14B structure of the proline directed phosphatase cdc14 2.5Å AUTH C.H.GRAY,V.M.GOOD,N.K.TONKS,D.BARFORDTITL THE STRUCTURE OF THE CELL CYCLE PROTEIN CDC14TITL 2 REVEALS A PROLINE-DIRECTED PROTEIN PHOSPHATASEREF EMBO J. V. 22 3524 2003REFN ISSN 0261-4189PMID 12853468DOI 10.1093/EMBOJ/CDG348 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rzu STAMBP the crystal structure of the catalytic domain of amsh 2.5Å AUTH C.W.DAVIES,L.N.PAUL,M.I.KIM,C.DASTITL STRUCTURAL AND THERMODYNAMIC COMPARISON OF THE CATALYTICTITL 2 DOMAIN OF AMSH AND AMSH-LP: NEARLY IDENTICAL FOLD BUTTITL 3 DIFFERENT STABILITY.REF J.MOL.BIOL. V. 413 416 2011REFN ISSN 0022-2836PMID 21888914DOI 10.1016/J.JMB.2011.08.029 Variant Set Distributions Mapped Variants
General Structure Information 4mbb DUSP11 cubic crystal form of pir1 dual specificity phosphatase core 1.85Å AUTH R.S.SANKHALA,R.K.LOKAREDDY,G.CINGOLANITITL STRUCTURE OF HUMAN PIR1, AN ATYPICAL DUAL-SPECIFICITYTITL 2 PHOSPHATASE.REF BIOCHEMISTRY V. 53 862 2014REFN ISSN 0006-2960PMID 24447265DOI 10.1021/BI401240X Variant Set Distributions Mapped Variants
General Structure Information 3puf RNASEH2A crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2jsd MMP20 solution structure of mmp20 complexed with nngh -1.0Å AUTH Y.ARENDT,L.BANCI,I.BERTINI,F.CANTINI,R.COZZI,AUTH 2 R.DEL CONTE,L.GONNELLITITL CATALYTIC DOMAIN OF MMP20 (ENAMELYSIN) – THE NMRTITL 2 STRUCTURE OF A NEW MATRIX METALLOPROTEINASE.REF FEBS LETT. V. 581 4723 2007REFN ISSN 0014-5793PMID 17869250DOI 10.1016/J.FEBSLET.2007.08.069 Variant Set Distributions Mapped Variants
General Structure Information 3ggr RAD1 crystal structure of the human rad9-hus1-rad1 complex 3.2Å AUTH M.XU,L.BAI,Y.GONG,W.XIE,H.Y.HANG,T.JIANGTITL STRUCTURE AND FUNCTIONAL IMPLICATIONS OF THE HUMANTITL 2 RAD9-HUS1-RAD1 CELL CYCLE CHECKPOINT COMPLEXREF J.BIOL.CHEM. V. 284 20457 2009REFN ISSN 0021-9258PMID 19535328DOI 10.1074/JBC.C109.022384 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3edi TLL1 crystal structure of tolloid-like protease 1 (tll-1) protease domain 1.4Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants