Assessment of Structural Intolerance and Durability
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 4knv NANP the crystal structure of apo human hdhd4 from se-mad 1.99Å AUTH S.H.KIM,K.L.CONSTANTINE,G.J.DUKE,V.GOLDFARB,J.T.HUNT,AUTH 2 S.JOHNSON,K.KISH,H.E.KLEI,P.A.MCDONNELL,W.J.METZLER,AUTH 3 L.MUELLER,M.A.POSS,C.R.FAIRCHILD,R.S.BHIDETITL DESIGN, SYNTHESIS, FUNCTIONAL AND STRUCTURALTITL 2 CHARACTERIZATION OF AN INHIBITOR OFTITL 3 N-ACETYLNEURAMINATE-9-PHOSPHATE PHOSPHATASE: OBSERVATION OFTITL 4 EXTENSIVE DYNAMICS IN AN ENZYME/INHIBITOR COMPLEX.REF BIOORG.MED.CHEM.LETT. V. 23 4107 2013REFN ISSN 0960-894XPMID 23747226DOI 10.1016/J.BMCL.2013.05.052 Variant Set […]
General Structure Information 3zjc GIMAP7 crystal structure of gmppnp-bound human gimap7 l100q variant 3.15Å AUTH D.SCHWEFEL,B.S.ARASU,S.F.MARINO,B.LAMPRECHT,K.KOECHERT,AUTH 2 E.ROSENBAUM,J.EICHHORST,B.WIESNER,J.BEHLKE,O.ROCKS,S.MATHAS,AUTH 3 O.DAUMKETITL STRUCTURAL INSIGHTS INTO THE MECHANISM OF GTPASE ACTIVATIONTITL 2 IN THE GIMAP FAMILY.REF STRUCTURE V. 21 550 2013REFN ISSN 0969-2126PMID 23454188DOI 10.1016/J.STR.2013.01.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qik PREX1 crystal structure of the first pdz domain of prex1 2.29Å AUTH L.SHEN,Y.TONG,W.TEMPEL,Y.LI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF PREX1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uzg USP33 zf-ubp domain of vdu1 -1.0Å AUTH M.D.ALLEN,M.BYCROFTTITL THE SOLUTION STRUCTURE OF THE ZNF UBP DOMAIN OFTITL 2 USP33/VDU1.REF PROTEIN SCI. V. 16 2072 2007REFN ISSN 0961-8368PMID 17766394DOI 10.1110/PS.072967807 Variant Set Distributions Mapped Variants
General Structure Information 3n9u CPSF7 crystal structure of the complex between the 25 kda subunit and the 59 kda subunit (rrm domain) of human cleavage factor im 1.92Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE 25 KDA SUBUNITTITL 2 AND THE […]
General Structure Information 3s4e DUSP19 crystal structrue of a novel mitogen-activated protein kinase phosphatase, skrp1 1.26Å AUTH C.H.WEI,S.Y.RYU,Y.H.JEON,M.Y.YOON,D.G.JEONG,S.J.KIM,S.E.RYUTITL CRYSTAL STRUCTURE OF A NOVEL MITOGEN-ACTIVATED PROTEINTITL 2 KINASE PHOSPHATASE, SKRP1.REF PROTEINS V. 79 3242 2011REFN ISSN 0887-3585PMID 21989941DOI 10.1002/PROT.23156 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4if8 SERPINA12 structure of vaspin 2.08Å AUTH J.T.HEIKER,N.KLOTING,P.KOVACS,E.B.KUETTNER,N.STRATER,AUTH 2 S.SCHULTZ,M.KERN,M.STUMVOLL,M.BLUHER,A.G.BECK-SICKINGERTITL VASPIN INHIBITS KALLIKREIN 7 BY SERPIN MECHANISMREF CELL.MOL.LIFE SCI. V. 70 2569 2013REFN ISSN 1420-682XPMID 23370777DOI 10.1007/S00018-013-1258-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2okv DTD1 c-myc dna unwinding element binding protein 2.0Å AUTH M.KEMP,B.BAE,J.P.YU,M.GHOSH,M.LEFFAK,S.K.NAIRTITL STRUCTURE AND FUNCTION OF THE C-MYC DNA-UNWINDINGTITL 2 ELEMENT-BINDING PROTEIN DUE-B.REF J.BIOL.CHEM. V. 282 10441 2007REFN ISSN 0021-9258PMID 17264083DOI 10.1074/JBC.M609632200 Variant Set Distributions Mapped Variants
General Structure Information 3u12 USP37 the pleckstrin homology (ph) domain of usp37 2.08Å AUTH A.DONG,U.B.NAIR,A.WERNIMONT,J.R.WALKER,J.WEIGELT,C.BOUNTRA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE PLECKSTRIN HOMOLOGY (PH) DOMAIN OF USP37REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants