Assessment of Structural Intolerance and Durability
General Structure Information 3zgo SIRT2 re-refined structure of the human sirt2 apoform 1.63Å AUTH S.MONIOT,M.SCHUTKOWSKI,C.STEEGBORNTITL CRYSTAL STRUCTURE ANALYSIS OF HUMAN SIRT2 AND ITSTITL 2 ADP-RIBOSE COMPLEXREF J.STRUCT.BIOL. V. 182 136 2013REFN ISSN 1047-8477PMID 23454361DOI 10.1016/J.JSB.2013.02.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vkc N4BP2 solution structure of the b3bp smr domain -1.0Å AUTH T.DIERCKS,E.AB,M.A.DANIELS,R.N.DE JONG,R.BESSELING,AUTH 2 R.KAPTEIN,G.E.FOLKERSTITL SOLUTION STRUCTURE AND CHARACTERIZATION OF THETITL 2 DNA- BINDING ACTIVITY OF THE B3BP-SMR DOMAIN.REF J.MOL.BIOL. V. 383 1156 2008REFN ISSN 0022-2836PMID 18804481DOI 10.1016/J.JMB.2008.09.005 Variant Set Distributions Mapped Variants
General Structure Information 1zbu ERI1 crystal structure of full-length 3-exonuclease 3.0Å AUTH Y.CHENG,D.J.PATELTITL STRUCTURAL BASIS FOR 3-END SPECIFIC RECOGNITION OF HISTONETITL 2 MRNA STEM-LOOP BY 3-EXONUCLEASE, A HUMAN NUCLEASE THAT ALSOTITL 3 TARGETS SIRNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ae8 THEM4 crystal structure of human them4 1.59Å AUTH E.ZHURAVLEVA,H.GUT,D.HYNX,D.MARCELLIN,C.K.E.BLECK,C.GENOUD,AUTH 2 P.CRON,J.J.KEUSCH,B.DUMMLER,M.D.ESPOSTI,B.A.HEMMINGSTITL ACYL COENZYME A THIOESTERASE THEM5/ACOT15 IS INVOLVED INTITL 2 CARDIOLIPIN REMODELING AND FATTY LIVER DEVELOPMENT.REF MOL.CELL.BIOL. V. 32 2685 2012REFN ISSN 0270-7306PMID 22586271DOI 10.1128/MCB.00312-12 Variant Set Distributions Mapped Variants
General Structure Information 3v33 ZC3H12A crystal structure of mcpip1 conserved domain with zinc-finger motif 2.0Å AUTH J.XU,W.PENG,Y.SUN,X.WANG,Y.XU,X.LI,G.GAO,Z.RAOTITL STRUCTURAL STUDY OF MCPIP1 N-TERMINAL CONSERVED DOMAINTITL 2 REVEALS A PIN-LIKE RNASEREF NUCLEIC ACIDS RES. V. 40 6957 2012REFN ISSN 0305-1048PMID 22561375DOI 10.1093/NAR/GKS359 Variant Set Distributions Mapped Variants
General Structure Information 3bpt HIBCH crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin 1.5Å AUTH E.S.PILKA,C.PHILLIPS,O.N.F.KING,K.GUO,F.VON DELFT,AUTH 2 A.C.W.PIKE,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COATITL 2 HYDROLASE IN COMPLEX WITH QUERCETIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hzj RABGAP1L crystal structure of the rabgap domain of the rabgap1l protein 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THETITL 2 RABGAP1L PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i1y PTPRN crystal structure of the phosphatase domain of human ptp ia-2 2.23Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,T.P.DILORENZO,AUTH 2 V.MALASHKEVICH,S.R.WASSERMAN,S.SWAMINATHAN,S.ESWARAMOORTHY,AUTH 3 R.AGARWAL,D.KUMARAN,M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,AUTH 4 J.ALVARADO,U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 5 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASESREF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2g6z DUSP5 crystal structure of human dusp5 2.7Å AUTH D.G.JEONG,Y.H.CHO,T.S.YOON,J.H.KIM,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 DUSP5, A DUAL SPECIFICITY MAP KINASE PROTEINTITL 3 PHOSPHATASEREF PROTEINS V. 66 253 2007REFN ISSN 0887-3585PMID 17078075DOI 10.1002/PROT.21224 Variant Set Distributions Mapped Variants
General Structure Information 4ad9 LACTB2 crystal structure of human lactb2. 2.6Å AUTH C.K.ALLERSTON,T.KROJER,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN LACTB2.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants