1ZBU.B | ERI1 – ASTRID

1ZBU.B | ERI1

General Structure Information

PDB ID	1zbu
HGNC Gene Label(s)	ERI1
Structure Name	crystal structure of full-length 3-exonuclease
Resolution	3.0Å
Reference	AUTH Y.CHENG,D.J.PATELTITL STRUCTURAL BASIS FOR 3-END SPECIFIC RECOGNITION OF HISTONETITL 2 MRNA STEM-LOOP BY 3-EXONUCLEASE, A HUMAN NUCLEASE THAT ALSOTITL 3 TARGETS SIRNAREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	294
Number Of SNVs	90
Number Of Permutations	60130
Optimal Distance Threshold	8.0
K Statistic	0.026
p-value	0.898

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
8:8865505		G>V	B:45	(98.61, -95.47, -44.64)
8:8865510		E>K	B:47	(95.72, -93.41, -40.13)
8:8865513		T>A	B:48	(91.77, -96.33, -39.57)
8:8865523	rs367704025	S>F	B:51	(99.96, -97.14, -39.77)
8:8865537	rs150186258	S>P	B:56	(109.95, -103.05, -32.95)
8:8865543		A>T	B:58	(113.21, -105.21, -27.83)
8:8865575		E>D	B:68	(110.88, -100.74, -23.68)
8:8865586	rs201643475	T>M	B:72	(103.77, -101.08, -25.86)
8:8865605		R>S	B:78	(96.79, -94.93, -27.69)
8:8865625		R>T	B:85	(89.88, -106.10, -35.73)
8:8865626		R>S	B:85	(89.88, -106.10, -35.73)
8:8865630		K>E	B:87	(98.59, -104.74, -35.71)
8:8865631		K>R	B:87	(98.59, -104.74, -35.71)
8:8865636	rs377678941	S>A	B:89	(95.94, -109.96, -39.07)
8:8865639		E>Q	B:90	(100.77, -108.09, -39.05)
8:8865644	COSM160836	F>L	B:91	(101.97, -110.52, -36.08)
8:8865655		T>S	B:95	(90.42, -111.73, -35.05)
8:8869063		D>V	B:100	(89.30, -106.86, -22.93)
8:8869092	rs201251857	Y>H	B:110	(103.61, -106.79, -29.24)
8:8869106		K>N	B:114	(112.29, -109.77, -26.75)
8:8869114		L>Q	B:117	(104.10, -100.54, -30.19)
8:8869125		N>D	B:121	(103.09, -88.57, -34.21)
8:8869126	rs138826421	N>S	B:121	(103.09, -88.57, -34.21)
8:8869131	rs139876860	A>P	B:123	(100.78, -84.84, -40.79)
8:8869138		S>N	B:125	(98.13, -85.87, -46.65)
8:8869143		Y>H	B:127	(92.22, -82.90, -49.38)
8:8869158		I>V	B:132	(84.36, -75.92, -55.91)
8:8869162		I>T	B:133	(80.27, -78.37, -57.14)
8:8869168		F>C	B:135	(74.70, -78.20, -58.66)
8:8869197		P>S	B:145	(57.03, -78.22, -51.07)
8:8869211		H>Q	B:149	(63.88, -79.06, -57.55)
8:8869215		I>L	B:151	(70.62, -79.97, -62.18)
8:8869234		V>A	B:157	(86.02, -74.60, -59.48)
8:8869246		T>M	B:161	(95.92, -76.64, -52.11)
8:8869249		H>L	B:162	(99.84, -77.28, -53.33)
8:8869252		T>S	B:163	(99.26, -72.58, -55.47)
8:8869255		L>S	B:164	(96.18, -70.98, -52.71)
8:8873835		D>N	B:168	(90.78, -75.60, -63.84)
8:8873836		D>G	B:168	(90.78, -75.60, -63.84)
8:8873838		T>A	B:169	(86.95, -72.85, -64.86)
8:8873839	rs150505422	T>M	B:169	(86.95, -72.85, -64.86)
8:8873846	rs200548227	Q>H	B:171	(79.67, -73.03, -67.38)
8:8873851		Y>C	B:173	(74.23, -73.85, -68.96)
8:8873872		T>I	B:180	(60.73, -78.31, -69.87)
8:8873880		S>T	B:183	(60.22, -70.01, -64.11)
8:8873896	rs374060224	S>I	B:188	(65.21, -63.90, -62.52)
8:8875808		D>G	B:195	(67.81, -70.54, -75.69)
8:8875817		D>G	B:198	(66.01, -75.40, -74.98)
8:8875820	rs375717269	R>T	B:199	(70.91, -74.12, -77.18)
8:8875826		D>V	B:201	(73.74, -81.54, -73.36)
8:8875829		T>I	B:202	(71.38, -84.61, -71.14)
8:8875860		D>E	B:212	(85.82, -87.00, -68.76)
8:8875863		W>C	B:213	(87.49, -82.22, -66.34)
8:8875885	rs149850300	T>A	B:221	(94.89, -91.00, -59.78)
8:8875915		G>C	B:231	(76.47, -76.87, -48.11)
8:8877868	rs141237678	D>V	B:234	(74.25, -78.98, -54.05)
8:8877881		F>L	B:238	(69.61, -79.90, -55.93)
8:8877884		L>F	B:239	(73.29, -85.19, -57.47)
8:8877897		Q>E	B:244	(66.41, -90.53, -58.16)
8:8877899	rs539445687	Q>H	B:244	(66.41, -90.53, -58.16)
8:8877900		L>V	B:245	(64.98, -87.88, -62.26)
8:8877904	rs77826393	S>N	B:246	(68.61, -89.78, -64.80)
8:8877913		K>R	B:249	(73.80, -96.33, -59.27)
8:8877931		K>R	B:255	(78.51, -91.06, -51.32)
8:8877932		K>N	B:255	(78.51, -91.06, -51.32)
8:8877943	rs369290666	N>S	B:259	(79.66, -77.81, -45.58)
8:8877948		R>W	B:261	(76.82, -72.42, -44.47)
8:8877964		N>S	B:266	(83.10, -74.71, -36.69)
8:8877970		Y>C	B:268	(86.18, -67.94, -39.10)
8:8887305	COSM3651589	P>S	B:271	(76.09, -68.21, -36.08)
8:8887309		R>K	B:272	(72.74, -71.60, -40.74)
8:8887318		T>S	B:275	(77.07, -68.91, -42.97)
8:8887327		T>R	B:278	(76.86, -62.39, -48.86)
8:8887330		I>T	B:279	(77.47, -62.63, -44.45)
8:8887355		D>E	B:287	(83.04, -57.44, -52.21)
8:8887359	rs375690423	D>N	B:289	(83.38, -61.07, -57.66)
8:8887365		R>W	B:291	(74.03, -63.09, -61.46)
8:8887366	COSM4138763	R>Q	B:291	(74.03, -63.09, -61.46)
8:8887369	rs370575982	P>L	B:292	(74.22, -63.39, -57.96)
8:8887372		H>R	B:293	(71.60, -66.91, -57.35)
8:8887395		N>D	B:301	(82.95, -66.08, -54.84)
8:8887405		R>Q	B:304	(87.09, -64.98, -53.27)
8:8887407	rs373909987	I>V	B:305	(85.77, -68.28, -48.81)
8:8887417		R>Q	B:308	(90.93, -65.38, -45.78)
8:8887422		L>F	B:310	(93.49, -72.72, -46.42)
8:8887446		I>L	B:318	(85.48, -84.41, -45.54)
8:8887448		I>M	B:318	(85.48, -84.41, -45.54)
8:8887452	rs188601499	E>K	B:320	(78.58, -83.31, -44.69)
8:8887464		A>T	B:324	(71.04, -94.41, -46.20)
8:8887479		S>R	B:329	(78.66, -86.04, -39.79)
8:8887480	rs370716656	S>N	B:329	(78.66, -86.04, -39.79)
8:8887489		S>C	B:332	(87.26, -84.25, -36.63)
8:8887492	rs141287911	S>Y	B:333	(89.11, -87.58, -35.89)
8:8887500		I>V	B:336	(92.88, -86.28, -44.28)
8:8887506	rs540348741	G>S	B:338	(90.26, -89.49, -50.16)
8:8887509		T>P	B:339	(87.83, -88.66, -53.04)
8:8887513		P>L	B:340	(87.11, -91.77, -54.82)
8:8887519		P>R	B:342	(86.12, -90.07, -60.83)
8:8887536		R>G	B:348	(68.89, -96.77, -60.68)
8:8887538		R>S	B:348	(68.89, -96.77, -60.68)
8:8887540		K>T	B:349	(68.41, -101.12, -64.86)
8:8887541	rs61750798	K>N	B:349	(68.41, -101.12, -64.86)