General Structure Information 1xkt FASN human fatty acid synthase: structure and substrate selectivity of the thioesterase domain 2.6Å AUTH B.CHAKRAVARTY,Z.GU,S.S.CHIRALA,S.J.WAKIL,AUTH 2 F.A.QUIOCHOTITL HUMAN FATTY ACID SYNTHASE: STRUCTURE AND SUBSTRATETITL 2 SELECTIVITY OF THE THIOESTERASE DOMAIN.REF PROC.NATL.ACAD.SCI.USA V. 101 15567 2004REFN ISSN 0027-8424PMID 15507492DOI 10.1073/PNAS.0406901101 Variant Set Distributions Mapped Variants
General Structure Information 2f5y RGS3 crystal structure of the pdz domain from human rgs-3 2.39Å AUTH E.UGOCHUKWU,G.BERRIDGE,C.JOHANSSON,C.SMEE,P.SAVITSKY,AUTH 2 N.BURGESS,S.COLEBROOK,X.YANG,J.ELKINS,D.DOYLE,A.TURNBULL,AUTH 3 E.PAPAGRIGORIOU,J.DEBRECZENI,G.BUNKOCZI,F.GORREC,AUTH 4 F.VON DELFT,C.ARROWSMITH,M.SUNDSTROM,J.WEIGELT,A.EDWARDSTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ger PYCR1 crystal structure and oxidative mechanism of human pyrroline-5- carboxylate reductase 3.1Å AUTH Z.MENG,Z.LOU,Z.LIU,M.LI,X.ZHAO,M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASEREF J.MOL.BIOL. V. 359 1364 2006REFN ISSN 0022-2836PMID 16730026DOI 10.1016/J.JMB.2006.04.053 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j72 CAPG crystal structure of mutant macrophage capping protein (cap g) with actin-severing activity in the ca2+-free form 2.5Å AUTH S.M.VOROBIEV,F.S.SOUTHWICK,B.STOROKOPYTOV,S.C.ALMOTITL CRYSTAL STRUCTURE OF MUTANT HUMAN MACROPHAGE CAPPING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3q8k FEN1 crystal structure of human flap endonuclease fen1 (wt) in complex with product 5-flap dna, sm3+, and k+ 2.2Å AUTH S.E.TSUTAKAWA,S.CLASSEN,B.R.CHAPADOS,A.S.ARVAI,L.D.FINGER,AUTH 2 G.GUENTHER,C.G.TOMLINSON,P.THOMPSON,A.H.SARKER,B.SHEN,AUTH 3 P.K.COOPER,J.A.GRASBY,J.A.TAINERTITL HUMAN FLAP ENDONUCLEASE STRUCTURES, DNA DOUBLE-BASETITL 2 FLIPPING, AND A UNIFIED UNDERSTANDING OF THE FEN1TITL 3 SUPERFAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 198 2011REFN ISSN 0092-8674PMID 21496641DOI 10.1016/J.CELL.2011.03.004 […]
General Structure Information 2rnr GTF2H1 solution structure of the complex between tfiie alpha c- terminal acidic domain and tfiih p62 ph domain -1.0Å AUTH M.OKUDA,A.TANAKA,M.SATOH,S.MIZUTA,M.TAKAZAWA,AUTH 2 Y.OHKUMA,Y.NISHIMURATITL STRUCTURAL INSIGHT INTO THE TFIIE-TFIIHTITL 2 INTERACTION: TFIIE AND P53 SHARE THE BINDINGTITL 3 REGION ON TFIIHREF EMBO J. V. 27 1161 2008REFN ISSN 0261-4189PMID 18354501DOI 10.1038/EMBOJ.2008.47 Variant […]
General Structure Information 4n6h OPRD1 1.8 a structure of the human delta opioid 7tm receptor (psi community target) 1.8Å AUTH G.FENALTI,P.M.GIGUERE,V.KATRITCH,X.P.HUANG,A.A.THOMPSON,AUTH 2 V.CHEREZOV,B.L.ROTH,R.C.STEVENSTITL MOLECULAR CONTROL OF DELTA-OPIOID RECEPTOR SIGNALLING.REF NATURE V. 506 191 2014REFN ISSN 0028-0836PMID 24413399DOI 10.1038/NATURE12944 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1emo FBN1 nmr study of a pair of fibrillin ca2+ binding epidermal growth factor-like domains, 22 structures -1.0Å AUTH A.K.DOWNING,V.KNOTT,J.M.WERNER,C.M.CARDY,AUTH 2 I.D.CAMPBELL,P.A.HANDFORDTITL SOLUTION STRUCTURE OF A PAIR OF CALCIUM-BINDINGTITL 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS: IMPLICATIONSTITL 3 FOR THE MARFAN SYNDROME AND OTHER GENETICTITL 4 DISORDERS.REF CELL(CAMBRIDGE,MASS.) V. 85 597 1996REFN ISSN 0092-8674PMID […]
General Structure Information 1mq0 CDA crystal structure of human cytidine deaminase 2.4Å AUTH S.J.CHUNG,J.C.FROMME,G.L.VERDINETITL STRUCTURE OF HUMAN CYTIDINE DEAMINASE BOUND TO A POTENTTITL 2 INHIBITORREF J.MED.CHEM. V. 48 658 2005REFN ISSN 0022-2623PMID 15689149DOI 10.1021/JM0496279 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants