Assessment of Structural Intolerance and Durability
General Structure Information 4eyc CAMP crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld) 1.9Å AUTH M.PAZGIER,B.ERICKSEN,M.LING,E.TOTH,J.SHI,X.LI,AUTH 2 A.GALLIHER-BECKLEY,L.LAN,G.ZOU,C.ZHAN,W.YUAN,E.POZHARSKI,AUTH 3 W.LUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PRO-DOMAIN OFTITL 2 HUMAN CATHELICIDIN, LL-37.REF BIOCHEMISTRY V. 52 1547 2013REFN ISSN 0006-2960PMID 23406372DOI 10.1021/BI301008R Variant Set Distributions Mapped Variants
General Structure Information 2olm AGFG1 arfgap domain of hiv-1 rev binding protein 1.48Å AUTH Y.TONG,W.TEMPEL,L.SHEN,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2es0 RGS6 structure of the regulator of g-protein signaling domain of rgs6 2.1Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3s9d IFNAR2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Mapped Variants
General Structure Information 3q2u GLIPR1 structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs. 1.85Å AUTH O.A.ASOJO,R.A.KOSKI,N.BONAFETITL STRUCTURAL STUDIES OF HUMAN GLIOMA PATHOGENESIS-RELATEDTITL 2 PROTEIN 1.REF ACTA CRYSTALLOGR.,SECT.D V. 67 847 2011REFN ISSN 0907-4449PMID 21931216DOI 10.1107/S0907444911028198 Variant Set Distributions Mapped Variants
General Structure Information 1z57 CLK1 crystal structure of human clk1 in complex with 10z-hymenialdisine 1.7Å AUTH A.N.BULLOCK,S.DAS,J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,AUTH 2 F.H.NIESEN,K.GUO,E.PAPAGRIGORIOU,A.L.AMOS,S.CHO,B.E.TURK,AUTH 3 G.GHOSH,S.KNAPPTITL KINASE DOMAIN INSERTIONS DEFINE DISTINCT ROLES OF CLKTITL 2 KINASES IN SR PROTEIN PHOSPHORYLATION.REF STRUCTURE V. 17 352 2009REFN ISSN 0969-2126PMID 19278650DOI 10.1016/J.STR.2008.12.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1zbq HSD17B4 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with nad 2.71Å AUTH P.LUKACIK,N.SHAFQAT,K.KAVANAGH,J.BRAY,F.VON DELFT,A.EDWARDS,AUTH 2 C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE 4 IN COMPLEX WITH NADREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mbs CCR5 crystal structure of the ccr5 chemokine receptor 2.71Å AUTH Q.TAN,Y.ZHU,J.LI,Z.CHEN,G.W.HAN,I.KUFAREVA,T.LI,L.MA,AUTH 2 G.FENALTI,J.LI,W.ZHANG,X.XIE,H.YANG,H.JIANG,V.CHEREZOV,AUTH 3 H.LIU,R.C.STEVENS,Q.ZHAO,B.WUTITL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR-HIV ENTRY INHIBITORTITL 2 MARAVIROC COMPLEX.REF SCIENCE V. 341 1387 2013REFN ISSN 0036-8075PMID 24030490DOI 10.1126/SCIENCE.1241475 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ikm POLG crystal structure of human mitochondrial dna polymerase holoenzyme 3.24Å AUTH Y.S.LEE,W.D.KENNEDY,Y.W.YINTITL STRUCTURAL INSIGHT INTO PROCESSIVE HUMANTITL 2 MITOCHONDRIAL DNA SYNTHESIS AND DISEASE-RELATEDTITL 3 POLYMERASE MUTATIONS.REF CELL(CAMBRIDGE,MASS.) V. 139 312 2009REFN ISSN 0092-8674PMID 19837034DOI 10.1016/J.CELL.2009.07.050 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3e0j POLD2 x-ray structure of the complex of regulatory subunits of human dna polymerase delta 3.0Å AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 Variant Set Distributions Mapped Variants