1J72.A | CAPG – ASTRID

1J72.A | CAPG

General Structure Information

PDB ID	1j72
HGNC Gene Label(s)	CAPG
Structure Name	crystal structure of mutant macrophage capping protein (cap g) with actin-severing activity in the ca2+-free form
Resolution	2.5Å
Reference	AUTH S.M.VOROBIEV,F.S.SOUTHWICK,B.STOROKOPYTOV,S.C.ALMOTITL CRYSTAL STRUCTURE OF MUTANT HUMAN MACROPHAGE CAPPING PROTEINREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	337
Number Of SNVs	95
Number Of Permutations	59354
Optimal Distance Threshold	29.0
K Statistic	0.404
p-value	0.999

COSMIC

Number Of Residues	337
Number Of SNVs	5
Number Of Permutations	598
Optimal Distance Threshold	21.0
K Statistic	0.1
p-value	0.442

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	95
Number Of COSMIC SNVs	5
Optimal Distance Threshold	18.0
K Statistic	-0.198
p-value	0.705

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:85629039		H>R	A:22	(-36.37, 86.82, -14.83)
2:85629031		R>W	A:25	(-33.44, 84.79, -2.10)
2:85629025		E>K	A:27	(-36.51, 83.81, 1.48)
2:85629012	rs140150295	P>L	A:31	(-40.84, 84.43, -4.35)
2:85629013		P>S	A:31	(-40.84, 84.43, -4.35)
2:85629003		V>A	A:34	(-32.13, 88.49, -7.05)
2:85629004		V>L	A:34	(-32.13, 88.49, -7.05)
2:85629000	rs142150224	A>V	A:35	(-30.42, 91.88, -6.87)
2:85628998		Q>E	A:36	(-29.53, 92.82, -10.39)
2:85628986	rs147213673	G>C	A:40	(-24.42, 84.89, -9.32)
2:85628983	rs2229668	V>I	A:41	(-24.46, 85.52, -5.94)
2:85628980	rs138195193	F>L	A:42	(-26.64, 81.56, -6.38)
2:85628973	rs373269135	S>L	A:44	(-25.88, 77.42, 0.18)
2:85628964		S>F	A:47	(-33.39, 77.51, -3.14)
2:85628958		L>P	A:49	(-36.77, 80.10, -9.06)
2:85628956		V>L	A:50	(-33.30, 80.79, -12.74)
2:85628949		H>R	A:52	(-33.31, 82.46, -20.31)
2:85628950		H>Y	A:52	(-33.31, 82.46, -20.31)
2:85628944		G>S	A:54	(-36.16, 84.48, -25.38)
2:85628924		H>Q	A:60	(-35.35, 77.23, -20.36)
2:85628791		R>Q	A:71	(-36.13, 68.09, -0.18)
2:85628762		A>P	A:81	(-42.03, 76.30, -9.98)
2:85628759		V>M	A:82	(-45.37, 74.83, -10.60)
2:85628731	rs371246622	R>P	A:91	(-45.22, 78.99, -22.25)
2:85628732	rs375004748	R>W	A:91	(-45.22, 78.99, -22.25)
2:85628726		V>L	A:93	(-37.98, 74.00, -19.97)
2:85628717		R>C	A:96	(-32.88, 68.92, -9.62)
2:85628714	COSM723025	E>Q	A:97	(-29.78, 72.92, -11.95)
2:85628704	rs35899313	G>D	A:100	(-21.92, 72.31, -8.55)
2:85628705		G>S	A:100	(-21.92, 72.31, -8.55)
2:85628691		D>E	A:104	(-23.52, 73.23, -19.57)
2:85628692		D>A	A:104	(-23.52, 73.23, -19.57)
2:85628690		L>F	A:105	(-28.09, 76.08, -20.21)
2:85628686		F>S	A:106	(-27.50, 77.71, -14.47)
2:85628684		M>V	A:107	(-23.07, 77.87, -15.83)
2:85628675		F>L	A:110	(-24.88, 83.03, -14.42)
2:85628669		R>W	A:112	(-18.48, 85.84, -14.86)
2:85628666		G>S	A:113	(-19.77, 83.47, -12.80)
2:85628445		G>D	A:120	(-23.59, 84.75, 7.15)
2:85628443	rs566095029	V>M	A:121	(-24.75, 88.27, 6.77)
2:85628389		L>F	A:138	(-36.91, 126.96, 27.26)
2:85628358	rs111495086	R>H	A:148	(-46.55, 124.83, 38.39)
2:85628359	rs200720697	R>C	A:148	(-46.55, 124.83, 38.39)
2:85628355		A>V	A:149	(-41.94, 124.35, 34.48)
2:85628349		E>V	A:151	(-41.57, 122.76, 26.81)
2:85628347	rs185763147	R>W	A:152	(-42.58, 127.71, 26.60)
2:85628340	rs377002350	L>Q	A:154	(-35.10, 127.46, 22.61)
2:85628314		D>N	A:163	(-40.27, 135.42, 34.60)
2:85628310	COSM1023351	C>Y	A:164	(-37.04, 132.65, 35.64)
2:85628311	rs568415860	C>G	A:164	(-37.04, 132.65, 35.64)
2:85628305		I>V	A:166	(-34.70, 126.31, 32.96)
2:85628296		L>V	A:169	(-28.66, 123.49, 26.38)
2:85626387		G>R	A:179	(-34.60, 141.49, 36.14)
2:85626365	rs201863934	R>H	A:186	(-31.52, 133.14, 41.46)
2:85626366		R>C	A:186	(-31.52, 133.14, 41.46)
2:85626362		N>S	A:187	(-33.33, 130.23, 44.42)
2:85626356		A>V	A:189	(-34.80, 127.97, 39.15)
2:85626350	rs201136347	D>G	A:191	(-33.64, 124.43, 42.93)
2:85626338	rs373962055	A>V	A:195	(-33.03, 118.67, 39.30)
2:85626332	rs368888036	R>Q	A:197	(-26.54, 118.80, 37.74)
2:85626333	rs11539103	R>W	A:197	(-26.54, 118.80, 37.74)
2:85626327	rs147589569	S>G	A:199	(-32.25, 113.59, 39.21)
2:85626320		R>Q	A:201	(-29.53, 111.61, 34.82)
2:85626303		V>M	A:207	(-25.83, 124.22, 36.70)
2:85626300		E>K	A:208	(-24.08, 128.48, 34.77)
2:85626294	rs552947160	V>I	A:210	(-27.92, 133.51, 33.91)
2:85626291		T>P	A:211	(-28.12, 137.67, 34.74)
2:85626284		G>A	A:213	(-27.58, 140.17, 30.03)
2:85626260		Q>R	A:221	(-25.60, 129.86, 19.80)
2:85625901		L>P	A:223	(-31.39, 132.03, 21.61)
2:85625892	rs117284777	K>R	A:226	(-30.44, 139.73, 24.08)
2:85625887	rs200233412	A>T	A:228	(-35.71, 143.24, 23.42)
2:85625857	rs193280469	L>V	A:238	(-54.92, 131.85, 30.82)
2:85625847		D>G	A:241	(-54.78, 128.13, 26.19)
2:85625839		N>H	A:244	(-54.31, 131.42, 20.66)
2:85625827	rs376003215 COSM1729641	A>T	A:248	(-47.84, 124.46, 15.04)
2:85625266		A>T	A:256	(-22.78, 120.98, 14.36)
2:85625259		G>E	A:258	(-21.19, 116.19, 17.09)
2:85625260		G>R	A:258	(-21.19, 116.19, 17.09)
2:85625256		Q>P	A:259	(-24.01, 115.34, 19.42)
2:85625253		M>K	A:260	(-28.09, 115.34, 16.37)
2:85625254		M>V	A:260	(-28.09, 115.34, 16.37)
2:85625240	rs149753250	K>N	A:264	(-39.57, 123.61, 20.35)
2:85625226		S>N	A:269	(-48.79, 131.12, 14.38)
2:85625223		P>L	A:270	(-46.86, 133.50, 12.85)
2:85625202		I>T	A:277	(-30.69, 127.87, 9.13)
2:85625200		S>T	A:278	(-29.11, 126.68, 5.22)
2:85625188		F>L	A:282	(-35.43, 123.14, 10.23)
2:85625175	rs549418687	N>S	A:286	(-49.58, 120.50, 11.11)
2:85625172	rs114733789	G>E	A:287	(-50.04, 116.74, 12.77)
2:85625158		I>L	A:292	(-45.31, 116.24, 9.57)
2:85625150	rs368826141	I>M	A:294	(-38.93, 117.43, 6.44)
2:85625143		G>W	A:297	(-30.99, 122.36, 3.55)
2:85622746	COSM172221	R>Q	A:298	(-29.82, 125.24, -0.46)
2:85622726	rs370308468	R>W	A:305	(-32.13, 114.04, 6.96)
2:85622699		G>S	A:314	(-41.86, 110.60, 17.11)
2:85622689		S>L	A:317	(-45.61, 108.41, 18.40)
2:85622687	COSM1023349	R>C	A:318	(-44.36, 112.16, 22.96)
2:85622683	rs375904794	M>T	A:319	(-47.94, 113.72, 19.85)
2:85622674		A>V	A:322	(-52.78, 109.50, 12.34)
2:85622675	rs566538644 COSM1409780	A>T	A:322	(-52.78, 109.50, 12.34)
2:85622671	COSM1247312 COSM1291542	P>L	A:323	(-50.81, 106.47, 11.82)
2:85622078		E>K	A:328	(-44.34, 117.18, 2.56)
2:85622062	rs377056776	G>D	A:333	(-36.86, 126.51, -2.63)
2:85622059	rs6886	H>R	A:334	(-37.05, 122.25, -5.34)
2:85622056	rs578014741	E>V	A:335	(-39.98, 125.79, -0.40)
2:85622051		P>T	A:337	(-47.31, 126.43, -1.20)
2:85622047		I>T	A:338	(-49.11, 124.73, 2.58)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:85629046	COSM3840153	G>S	A:20	(-34.89, 87.29, -20.11)
2:85629031	COSM3001701	R>W	A:25	(-33.44, 84.79, -2.10)
2:85628290	COSM3659996	Q>K	A:171	(-23.07, 119.42, 28.32)
2:85622700	COSM1615174	E>D	A:313	(-42.22, 108.75, 12.59)
2:85622055	COSM1247310	E>D	A:335	(-39.98, 125.79, -0.40)

1J72.A | CAPG.

1J72.A | CAPG

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants