Assessment of Structural Intolerance and Durability
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4akm LAMP3 crystal structure of the human lysosome-associated membrane protein lamp-3 (aka dc-lamp) 2.69Å AUTH S.WILKE,J.KRAUSZE,K.BUSSOWTITL CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN OF THE DCTITL 2 LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN: IMPLICATIONS FOR THETITL 3 LYSOSOMAL GLYCOCALYX.REF BMC BIOL. V. 10 62 2012REFN ISSN 1741-7007PMID 22809326DOI 10.1186/1741-7007-10-62 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b2d CD180 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2fue PMM1 human alpha-phosphomannomutase 1 with d-mannose 1-phosphate and mg2+ cofactor bound 1.75Å AUTH N.R.SILVAGGI,C.ZHANG,Z.LU,J.DAI,D.DUNAWAY-MARIANO,K.N.ALLENTITL THE X-RAY CRYSTAL STRUCTURES OF HUMANTITL 2 ALPHA-PHOSPHOMANNOMUTASE 1 REVEAL THE STRUCTURAL BASIS OFTITL 3 CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1A.REF J.BIOL.CHEM. V. 281 14918 2006REFN ISSN 0021-9258PMID 16540464DOI 10.1074/JBC.M601505200 Variant Set Distributions Mapped Variants
General Structure Information 4hsa IL17RA structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 4e36 ERAP2 crystal structure of the human endoplasmic reticulum aminopeptidase 2 variant n392k 3.22Å AUTH I.EVNOUCHIDOU,J.BIRTLEY,S.SEREGIN,A.PAPAKYRIAKOU,E.ZERVOUDI,AUTH 2 M.SAMIOTAKI,G.PANAYOTOU,P.GIASTAS,O.PETRAKIS,D.GEORGIADIS,AUTH 3 A.AMALFITANO,E.SARIDAKIS,I.M.MAVRIDIS,E.STRATIKOSTITL A COMMON SINGLE NUCLEOTIDE POLYMORPHISM IN ENDOPLASMICTITL 2 RETICULUM AMINOPEPTIDASE 2 INDUCES A SPECIFICITY SWITCH THATTITL 3 LEADS TO ALTERED ANTIGEN PROCESSING.REF J.IMMUNOL. V. 189 2383 2012REFN ISSN 0022-1767PMID 22837489DOI 10.4049/JIMMUNOL.1200918 Variant […]
General Structure Information 4dkd IL34 crystal structure of human interleukin-34 bound to human csf-1r 3.0Å AUTH X.MA,W.Y.LIN,Y.CHEN,S.STAWICKI,K.MUKHYALA,Y.WU,F.MARTIN,AUTH 2 J.F.BAZAN,M.A.STAROVASNIKTITL STRUCTURAL BASIS FOR THE DUAL RECOGNITION OF HELICALTITL 2 CYTOKINES IL-34 AND CSF-1 BY CSF-1R.REF STRUCTURE V. 20 676 2012REFN ISSN 0969-2126PMID 22483114DOI 10.1016/J.STR.2012.02.010 Variant Set Distributions Mapped Variants
General Structure Information 4hsa IL17A structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants