Assessment of Structural Intolerance and Durability
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1zxq ICAM2 the crystal structure of icam-2 2.2Å AUTH J.M.CASASNOVAS,T.A.SPRINGER,J.H.LIU,S.C.HARRISON,J.H.WANGTITL CRYSTAL STRUCTURE OF ICAM-2 REVEALS A DISTINCTIVE INTEGRINTITL 2 RECOGNITION SURFACE.REF NATURE V. 387 312 1997REFN ISSN 0028-0836PMID 9153399DOI 10.1038/387312A0 Variant Set Distributions Mapped Variants
General Structure Information 2iwg TRIM21 complex between the pryspry domain of trim21 and igg fc 2.35Å AUTH L.C.JAMES,A.H.KEEBLE,Z.KHAN,D.A.RHODES,J.TROWSDALETITL STRUCTURAL BASIS FOR PRYSPRY-MEDIATED TRIPARTITETITL 2 MOTIF (TRIM) PROTEIN FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 6200 2007REFN ISSN 0027-8424PMID 17400754DOI 10.1073/PNAS.0609174104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ry6 FCGR2A complex of fcgammariia (cd32) and the fc of human igg1 3.8Å AUTH P.A.RAMSLAND,W.FARRUGIA,T.M.BRADFORD,C.T.SARDJONO,S.ESPARON,AUTH 2 H.M.TRIST,M.S.POWELL,P.S.TAN,A.C.CENDRON,B.D.WINES,AUTH 3 A.M.SCOTT,P.M.HOGARTHTITL STRUCTURAL BASIS FOR FC{GAMMA}RIIA RECOGNITION OF HUMAN IGGTITL 2 AND FORMATION OF INFLAMMATORY SIGNALING COMPLEXES.REF J.IMMUNOL. V. 187 3208 2011REFN ISSN 0022-1767PMID 21856937DOI 10.4049/JIMMUNOL.1101467 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3hng FLT1 crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide 2.7Å AUTH L.TRESAUGUES,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,T.NYMAN,C.PERSSON,T.KRAGH-NIELSEN,AUTH 5 A.KOTZCH,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,S.VAN DER BERG,J.WEIGELT,M.WELIN,AUTH 7 M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITHTITL 2 N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3vwk CD1D ternary crystal structure of the human nkt tcr-cd1d-4deoxy-alpha- galactosylceramide complex 2.94Å AUTH K.S.WUN,F.ROSS,O.PATEL,G.S.BESRA,S.A.PORCELLI,AUTH 2 S.K.RICHARDSON,S.KESHIPEDDY,A.R.HOWELL,D.I.GODFREY,AUTH 3 J.ROSSJOHNTITL HUMAN AND MOUSE TYPE I NATURAL KILLER T CELL ANTIGENTITL 2 RECEPTORS EXHIBIT DIFFERENT FINE SPECIFICITIES FORTITL 3 CD1D-ANTIGEN COMPLEXREF J.BIOL.CHEM. V. 287 39139 2012REFN ISSN 0021-9258PMID 22995911DOI 10.1074/JBC.M112.412320 Variant Set Distributions Ripley’s […]
General Structure Information 3lqz HLA-DPA1 crystal structure of hla-dp2 3.25Å AUTH S.DAI,G.A.MURPHY,F.CRAWFORD,D.G.MACK,M.T.FALTA,P.MARRACK,AUTH 2 J.W.KAPPLER,A.P.FONTENOTTITL CRYSTAL STRUCTURE OF HLA-DP2 AND IMPLICATIONS FOR CHRONICTITL 2 BERYLLIUM DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 107 7425 2010REFN ISSN 0027-8424PMID 20356827DOI 10.1073/PNAS.1001772107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qty FLT1 vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor 2.7Å AUTH M.A.STAROVASNIK,H.W.CHRISTINGER,C.WIESMANN,AUTH 2 M.A.CHAMPE,A.M.DE VOS,N.J.SKELTONTITL SOLUTION STRUCTURE OF THE VEGF-BINDING DOMAIN OFTITL 2 FLT-1: COMPARISON OF ITS FREE AND BOUND STATES.REF J.MOL.BIOL. V. 293 531 1999REFN ISSN 0022-2836PMID 10543948DOI 10.1006/JMBI.1999.3134 Variant Set Distributions Ripley’s K Analysis […]