2VDY.A | SERPINA6

General Structure Information 2vdy SERPINA6 crystal structure of the reactive loop cleaved corticosteroid binding globulin complexed with cortisol 2.3Å AUTH A.ZHOU,Z.WEI,P.L.STANLEY,R.J.READ,P.E.STEIN,R.W.CARRELLTITL THE S-TO-R TRANSITION OF CORTICOSTEROID-BINDING GLOBULINTITL 2 AND THE MECHANISM OF HORMONE RELEASE.REF J.MOL.BIOL. V. 380 244 2008REFN ISSN 0022-2836PMID 18513745DOI 10.1016/J.JMB.2008.05.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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1R1J.A | MME

General Structure Information 1r1j MME structural analysis of neprilysin with various specific and potent inhibitors 2.35Å AUTH C.OEFNER,B.P.ROQUES,M.C.FOURNIE-ZALUSKI,G.E.DALETITL STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC ANDTITL 2 POTENT INHIBITORS.REF ACTA CRYSTALLOGR.,SECT.D V. 60 392 2004REFN ISSN 0907-4449PMID 14747736DOI 10.1107/S0907444903027410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3BU6.A | INSR

General Structure Information 3bu6 INSR crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide 1.95Å AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

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2UZX.B | MET

General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]

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1UX6.A | THBS1

General Structure Information 1ux6 THBS1 structure of a thrombospondin c-terminal fragment reveals a novel calcium core in the type 3 repeats 1.9Å AUTH M.KVANSAKUL,J.C.ADAMS,E.HOHENESTERTITL STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENTTITL 2 REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATSREF EMBO J. V. 23 1223 2004REFN ISSN 0261-4189PMID 15014436DOI 10.1038/SJ.EMBOJ.7600166 Variant Set Distributions Ripley’s […]

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3LCO.A | CSF1R

General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]

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1JLM.A | ITGAM

General Structure Information 1jlm ITGAM i-domain from integrin cr3, mn2+ bound 2.0Å AUTH J.O.LEE,L.A.BANKSTON,M.A.ARNAOUT,R.C.LIDDINGTONTITL TWO CONFORMATIONS OF THE INTEGRIN A-DOMAINTITL 2 (I-DOMAIN): A PATHWAY FOR ACTIVATION?REF STRUCTURE V. 3 1333 1995REFN ISSN 0969-2126PMID 8747460DOI 10.1016/S0969-2126(01)00271-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2V53.A | SPARC

General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4ADF.K | CSF1

General Structure Information 4adf CSF1 crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in complex with the viral receptor barf1 4.4Å AUTH J.ELEGHEERT,N.BRACKE,P.POULIOT,I.GUTSCHE,A.V.SHKUMATOV,AUTH 2 N.TARBOURIECH,K.VERSTRAETE,A.BEKAERT,W.P.BURMEISTER,AUTH 3 D.I.SVERGUN,B.N.LAMBRECHT,B.VERGAUWEN,S.N.SAVVIDESTITL ALLOSTERIC COMPETITIVE INACTIVATION OF HEMATOPOIETIC CSF-1TITL 2 SIGNALING BY THE VIRAL DECOY RECEPTOR BARF1.REF NAT.STRUCT.MOL.BIOL. V. 19 938 2012REFN ISSN 1545-9993PMID 22902366DOI 10.1038/NSMB.2367 Variant Set Distributions […]

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3LXC.A | GLA

General Structure Information 3lxc GLA interconversion of human lysosomal enzyme specificities 2.35Å AUTH I.B.TOMASIC,M.C.METCALF,A.I.GUCE,N.E.CLARK,S.C.GARMANTITL INTERCONVERSION OF THE SPECIFICITIES OF HUMAN LYSOSOMALTITL 2 ENZYMES ASSOCIATED WITH FABRY AND SCHINDLER DISEASES.REF J.BIOL.CHEM. V. 285 21560 2010REFN ISSN 0021-9258PMID 20444686DOI 10.1074/JBC.M110.118588 Variant Set Distributions Mapped Variants

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