Assessment of Structural Intolerance and Durability
General Structure Information 3bk3 BMP2 crystal structure of the complex of bmp-2 and the first von willebrand domain type c of crossveinless-2 2.7Å AUTH J.-L.ZHANG,L.-Y.QIU,A.KOTZSCH,S.WEIDAUER,AUTH 2 L.PATTERSON,M.HAMMERSCHMIDT,W.SEBALD,T.D.MUELLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS HOW THE CHORDINTITL 2 FAMILY MEMBER CROSSVEINLESS 2 BLOCKS BMP-2TITL 3 RECEPTOR BINDINGREF DEV.CELL V. 14 739 2008REFN ISSN 1534-5807PMID 18477456DOI 10.1016/J.DEVCEL.2008.02.017 Variant Set […]
General Structure Information 1j89 FCER1A human high affinity fc receptor fc(epsilon)ri(alpha), tetragonal crystal form 2 4.1Å AUTH S.C.GARMAN,S.SECHI,J.P.KINET,T.S.JARDETZKYTITL THE ANALYSIS OF THE HUMAN HIGH AFFINITY IGE RECEPTOR FCTITL 2 EPSILON RI ALPHA FROM MULTIPLE CRYSTAL FORMS.REF J.MOL.BIOL. V. 311 1049 2001REFN ISSN 0022-2836PMID 11531339DOI 10.1006/JMBI.2001.4929 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2c6f ACE structure of human somatic angiontensin-i converting enzyme n domain 3.01Å AUTH H.R.CORRADI,S.L.U.SCHWAGER,A.T.NCHINDA,AUTH 2 E.D.STURROCK,K.R.ACHARYATITL CRYSTAL STRUCTURE OF THE N DOMAIN OF HUMAN SOMATICTITL 2 ANGIOTENSIN I-CONVERTING ENZYME PROVIDES ATITL 3 STRUCTURAL BASIS FOR DOMAIN-SPECIFIC INHIBITORTITL 4 DESIGN.REF J.MOL.BIOL. V. 357 964 2006REFN ISSN 0022-2836PMID 16476442DOI 10.1016/J.JMB.2006.01.048 Variant Set Distributions Ripley’s […]
General Structure Information 4js2 ST6GAL1 crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cmp 2.3Å AUTH B.KUHN,J.BENZ,M.GREIF,A.M.ENGEL,H.SOBEK,M.G.RUDOLPHTITL THE STRUCTURE OF HUMAN ALPHA-2,6-SIALYLTRANSFERASE REVEALSTITL 2 THE BINDING MODE OF COMPLEX GLYCANSREF ACTA CRYSTALLOGR.,SECT.D V. 69 1826 2013REFN ISSN 0907-4449DOI 10.1107/S0907444913015412 Variant Set Distributions Mapped Variants
General Structure Information 3cfw SELL l-selectin lectin and egf domains 2.2Å AUTH P.MEHTA,R.P.MCEVERTITL STRUCTURE OF LECTIN AND EGF DOMAINS OF L-SELECTINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 1itq DPEP1 human renal dipeptidase 2.3Å AUTH Y.NITANAI,Y.SATOW,H.ADACHI,M.TSUJIMOTOTITL CRYSTAL STRUCTURE OF HUMAN RENAL DIPEPTIDASE INVOLVED INTITL 2 BETA-LACTAM HYDROLYSISREF J.MOL.BIOL. V. 321 177 2002REFN ISSN 0022-2836PMID 12144777DOI 10.1016/S0022-2836(02)00632-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fsu ARSB 4-sulfatase (human) 2.5Å AUTH C.S.BOND,P.R.CLEMENTS,S.J.ASHBY,C.A.COLLYER,S.J.HARROP,AUTH 2 J.J.HOPWOOD,J.M.GUSSTITL STRUCTURE OF A HUMAN LYSOSOMAL SULFATASE.REF STRUCTURE V. 5 277 1997REFN ISSN 0969-2126PMID 9032078DOI 10.1016/S0969-2126(97)00185-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lpo SI crystal structure of the n-terminal domain of sucrase-isomaltase 3.2Å AUTH L.SIM,C.WILLEMSMA,S.MOHAN,H.Y.NAIM,B.M.PINTO,D.R.ROSETITL STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN HUMANTITL 2 MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE N-TERMINALTITL 3 DOMAINS.REF J.BIOL.CHEM. V. 285 17763 2010REFN ISSN 0021-9258PMID 20356844DOI 10.1074/JBC.M109.078980 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants