Assessment of Structural Intolerance and Durability
General Structure Information 3aqg ZG16B crystal structure of human pancreatic secretory protein zg16b 2.75Å AUTH M.KANAGAWA,T.SATOH,A.IKEDA,Y.NAKANO,H.YAGI,K.KATO,AUTH 2 K.KOJIMA-AIKAWA,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF HUMAN SECRETORY PROTEINS ZG16P ANDTITL 2 ZG16B REVEAL A JACALIN-RELATED BETA-PRISM FOLDREF BIOCHEM.BIOPHYS.RES.COMMUN. 2010REFN ESSN 1090-2104PMID 21110947DOI 10.1016/J.BBRC.2010.11.093 Variant Set Distributions Mapped Variants
General Structure Information 2i46 ACD crystal structure of human tpp1 2.7Å AUTH F.WANG,E.R.PODELL,A.J.ZAUG,Y.YANG,P.BACIU,T.R.CECH,AUTH 2 M.LEITITL THE POT1-TPP1 TELOMERE COMPLEX IS A TELOMERASETITL 2 PROCESSIVITY FACTOR.REF NATURE V. 445 506 2007REFN ISSN 0028-0836PMID 17237768DOI 10.1038/NATURE05454 Variant Set Distributions Mapped Variants
General Structure Information 3hbw FGF13 crystal structure of human fibroblast growth factor homologous factor 2a (fhf2a), also referred to as fibroblast growth factor 13a (fgf13a) 1.9Å AUTH R.GOETZ,K.DOVER,F.LAEZZA,N.SHTRAIZENT,X.HUANG,AUTH 2 D.TCHETCHIK,A.V.ELISEENKOVA,C.F.XU,T.A.NEUBERT,AUTH 3 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL CRYSTAL STRUCTURE OF A FIBROBLAST GROWTH FACTORTITL 2 HOMOLOGOUS FACTOR (FHF) DEFINES A CONSERVED SURFACETITL 3 ON FHFS FOR BINDING AND MODULATION OF […]
General Structure Information 2l2d OTUD7A solution nmr structure of human uba-like domain of otud7a_11_83, nesg target ht6304a/ocsp target otud7a_11_83/sgc-toronto -1.0Å AUTH B.WU,A.ASINAS,A.YEE,R.DOHERTY,A.LEMAK,A.GUTMANAS,AUTH 2 S.HOULISTON,A.SEMESI,C.H.ARROWSMITH,G.T.MONTELIONE,AUTH 3 S.DHE-PAGANONTITL THE AMINO-TERMINAL UBA DOMAIN OF OTUD7AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ph9 AGR3 crystal structure of the human anterior gradient protein 3 1.83Å AUTH V.D.NGUYEN,L.W.RUDDOCK,M.SALIN,R.K.WIERENGATITL CRYSTAL STRUCTURE OF THE HUMAN ANTERIOR GRADIENT PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d7r GALNT10 crystal structure of pp-galnac-t10 complexed with galnac-ser on lectin domain 2.8Å AUTH T.KUBOTA,T.SHIBA,S.SUGIOKA,S.FURUKAWA,H.SAWAKI,R.KATO,AUTH 2 S.WAKATSUKI,H.NARIMATSUTITL STRUCTURAL BASIS OF CARBOHYDRATE TRANSFER ACTIVITY BY HUMANTITL 2 UDP-GALNAC: POLYPEPTIDETITL 3 ALPHA-N-ACETYLGALACTOSAMINYLTRANSFERASE (PP-GALNAC-T10)REF J.MOL.BIOL. V. 359 708 2006REFN ISSN 0022-2836PMID 16650853DOI 10.1016/J.JMB.2006.03.061 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oci BPHL crystal structure of valacyclovir hydrolase complexed with a product analogue 1.9Å AUTH L.LAI,Z.XU,J.ZHOU,K.D.LEE,G.L.AMIDONTITL MOLECULAR BASIS OF PRODRUG ACTIVATION BY HUMANTITL 2 VALACYCLOVIRASE, AN ALPHA-AMINO ACID ESTERTITL 3 HYDROLASE.REF J.BIOL.CHEM. V. 283 9318 2008REFN ISSN 0021-9258PMID 18256025DOI 10.1074/JBC.M709530200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3k2i ACOT4 human acyl-coenzyme a thioesterase 4 2.4Å AUTH M.I.SIPONEN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,P.KRAULIS,T.KOTENYOVA,AUTH 5 A.KOTZSCH,N.MARKOVA,T.K.NIELSEN,P.NORDLUND,T.NYMAN,AUTH 6 C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,AUTH 7 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,AUTH 8 E.WAHLBERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,H.SCHULERTITL HUMAN ACYL-COENZYME A THIOESTERASE 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zb7 PTGR2 crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with nadph and nicotinamide 1.8Å AUTH Y.H.WU,T.P.KO,R.T.GUO,S.M.HU,L.M.CHUANG,A.H.J.WANGTITL STRUCTURAL BASIS FOR CATALYTIC AND INHIBITORYTITL 2 MECHANISMS OF HUMAN PROSTAGLANDIN REDUCTASE PTGR2.REF STRUCTURE V. 16 1714 2008REFN ISSN 0969-2126PMID 19000823DOI 10.1016/J.STR.2008.09.007 Variant Set Distributions Mapped Variants
General Structure Information 3cyn GPX8 the structure of human gpx8 2.0Å AUTH K.L.KAVANAGH,C.JOHANSSON,W.W.YUE,G.KOCHAN,U.OPPERMANNTITL THE STRUCTURE OF HUMAN GPX8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants