Assessment of Structural Intolerance and Durability
General Structure Information 3q2t CPSF6 crystal structure of cfim68 rrm/cfim25/rna complex 3.06Å AUTH Q.YANG,M.COSENO,G.M.GILMARTIN,S.DOUBLIETITL CRYSTAL STRUCTURE OF A HUMAN CLEAVAGE FACTORTITL 2 CFI(M)25/CFI(M)68/RNA COMPLEX PROVIDES AN INSIGHT INTOTITL 3 POLY(A) SITE RECOGNITION AND RNA LOOPING.REF STRUCTURE V. 19 368 2011REFN ISSN 0969-2126PMID 21295486DOI 10.1016/J.STR.2010.12.021 Variant Set Distributions Mapped Variants
General Structure Information 3se2 PARP14 human poly(adp-ribose) polymerase 14 (parp14/artd8) – catalytic domain in complex with 6(5h)-phenanthridinone 2.3Å AUTH E.WAHLBERG,T.KARLBERG,E.KOUZNETSOVA,N.MARKOVA,A.MACCHIARULO,AUTH 2 A.G.THORSELL,E.POL,A.FROSTELL,T.EKBLAD,D.ONCU,B.KULL,AUTH 3 G.M.ROBERTSON,R.PELLICCIARI,H.SCHULER,J.WEIGELTTITL FAMILY-WIDE CHEMICAL PROFILING AND STRUCTURAL ANALYSIS OFTITL 2 PARP AND TANKYRASE INHIBITORS.REF NAT.BIOTECHNOL. V. 30 283 2012REFN ISSN 1087-0156PMID 22343925DOI 10.1038/NBT.2121 Variant Set Distributions Mapped Variants
General Structure Information 3r2w UGP2 crystal strucutre of udp-glucose pyrophosphorylase of homo sapiens 3.6Å AUTH Q.YU,X.ZHENGTITL THE CRYSTAL STRUCTURE OF HUMAN UDP-GLUCOSE PYROPHOSPHORYLASETITL 2 REVEALS A LATCH EFFECT THAT INFLUENCES ENZYMATIC ACTIVITY.REF BIOCHEM.J. V. 442 283 2012REFN ISSN 0264-6021PMID 22132858DOI 10.1042/BJ20111598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3u0v LYPLAL1 crystal structure analysis of human lyplal1 1.72Å AUTH M.BURGER,T.J.ZIMMERMANN,Y.KONDOH,P.STEGE,N.WATANABE,H.OSADA,AUTH 2 H.WALDMANN,I.R.VETTERTITL CRYSTAL STRUCTURE OF THE PREDICTED PHOSPHOLIPASE LYPLAL1TITL 2 REVEALS UNEXPECTED FUNCTIONAL PLASTICITY DESPITE CLOSETITL 3 RELATIONSHIP TO ACYL PROTEIN THIOESTERASESREF J.LIPID RES. V. 53 43 2012REFN ISSN 0022-2275PMID 22052940DOI 10.1194/JLR.M019851 Variant Set Distributions Mapped Variants
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 4hon KDM4D crystal structure of human jmjd2d/kdm4d in complex with an h3k9me3 peptide and 2-oxoglutarate 1.8Å AUTH S.KRISHNAN,R.C.TRIEVELTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF JMJD2D REVEALSTITL 2 MOLECULAR BASIS FOR SITE-SPECIFIC DEMETHYLATION AMONG JMJD2TITL 3 DEMETHYLASES.REF STRUCTURE V. 21 98 2013REFN ISSN 0969-2126PMID 23219879DOI 10.1016/J.STR.2012.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4lp5 AGER crystal structure of the full-length human rage extracellular domain (vc1c2 fragment) 3.8Å AUTH L.YATIME,G.R.ANDERSENTITL STRUCTURAL INSIGHTS INTO THE OLIGOMERIZATION MODE OF THETITL 2 HUMAN RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS.REF FEBS J. V. 280 6556 2013REFN ISSN 1742-464XPMID 24119142DOI 10.1111/FEBS.12556 Variant Set Distributions Mapped Variants
General Structure Information 2rn9 COX17 solution structure of human apocox17 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,A.JANICKA,AUTH 2 M.MARTINELLI,H.KOZLOWSKI,P.PALUMAATITL A STRUCTURAL-DYNAMICAL CHARACTERIZATION OF HUMANTITL 2 COX17REF J.BIOL.CHEM. V. 283 7912 2008REFN ISSN 0021-9258PMID 18093982DOI 10.1074/JBC.M708016200 Variant Set Distributions Mapped Variants
General Structure Information 2i6k IDI1 crystal structure of human type i ipp isomerase complexed with a substrate analog 2.0Å AUTH C.ZHANG,L.LIU,H.XU,Z.WEI,Y.WANG,Y.LIN,W.GONGTITL CRYSTAL STRUCTURES OF HUMAN IPP ISOMERASE: NEWTITL 2 INSIGHTS INTO THE CATALYTIC MECHANISMREF J.MOL.BIOL. V. 366 1437 2007REFN ISSN 0022-2836PMID 17137593DOI 10.1016/J.JMB.2006.10.092 Variant Set Distributions Mapped Variants
General Structure Information 4i6x PDIA5 crystal structure of non-catalyic domain of protein disulfide isomerase-related (pdir) protein 1.5Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL STRUCTURE OF THE NON-CATALYTIC DOMAIN OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN (PDIR) REVEALS FUNCTIONTITL 3 IN PROTEIN BINDING.REF PLOS ONE V. 8 62021 2013REFN ESSN 1932-6203PMID 23614004DOI 10.1371/JOURNAL.PONE.0062021 Variant Set Distributions Mapped Variants