Assessment of Structural Intolerance and Durability
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 3ii5 BRAF the complex of wild-type b-raf with pyrazolo pyrimidine inhibitor 2.79Å AUTH D.M.BERGER,N.TORRES,M.DUTIA,D.POWELL,G.CISZEWSKI,AUTH 2 A.GOPALSAMY,J.I.LEVIN,K.H.KIM,W.XU,J.WILHELM,Y.HU,AUTH 3 K.COLLINS,L.FELDBERG,S.KIM,E.FROMMER,AUTH 4 D.WOJCIECHOWICZ,R.MALLONTITL NON-HINGE-BINDING PYRAZOLO[1,5-A]PYRIMIDINES ASTITL 2 POTENT B-RAF KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6519 2009REFN ISSN 0960-894XPMID 19864136DOI 10.1016/J.BMCL.2009.10.049 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dzu RXRA intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide 3.2Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3dyd TAT human tyrosine aminotransferase 2.3Å AUTH T.KARLBERG,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 K.OLESEN,C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 H.SCHULER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN TYROSINE AMINOTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lpo SI crystal structure of the n-terminal domain of sucrase-isomaltase 3.2Å AUTH L.SIM,C.WILLEMSMA,S.MOHAN,H.Y.NAIM,B.M.PINTO,D.R.ROSETITL STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN HUMANTITL 2 MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE N-TERMINALTITL 3 DOMAINS.REF J.BIOL.CHEM. V. 285 17763 2010REFN ISSN 0021-9258PMID 20356844DOI 10.1074/JBC.M109.078980 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]
General Structure Information 3g33 CDK4 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3vwk CD1D ternary crystal structure of the human nkt tcr-cd1d-4deoxy-alpha- galactosylceramide complex 2.94Å AUTH K.S.WUN,F.ROSS,O.PATEL,G.S.BESRA,S.A.PORCELLI,AUTH 2 S.K.RICHARDSON,S.KESHIPEDDY,A.R.HOWELL,D.I.GODFREY,AUTH 3 J.ROSSJOHNTITL HUMAN AND MOUSE TYPE I NATURAL KILLER T CELL ANTIGENTITL 2 RECEPTORS EXHIBIT DIFFERENT FINE SPECIFICITIES FORTITL 3 CD1D-ANTIGEN COMPLEXREF J.BIOL.CHEM. V. 287 39139 2012REFN ISSN 0021-9258PMID 22995911DOI 10.1074/JBC.M112.412320 Variant Set Distributions Ripley’s […]
General Structure Information 2vdy SERPINA6 crystal structure of the reactive loop cleaved corticosteroid binding globulin complexed with cortisol 2.3Å AUTH A.ZHOU,Z.WEI,P.L.STANLEY,R.J.READ,P.E.STEIN,R.W.CARRELLTITL THE S-TO-R TRANSITION OF CORTICOSTEROID-BINDING GLOBULINTITL 2 AND THE MECHANISM OF HORMONE RELEASE.REF J.MOL.BIOL. V. 380 244 2008REFN ISSN 0022-2836PMID 18513745DOI 10.1016/J.JMB.2008.05.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]