Assessment of Structural Intolerance and Durability
General Structure Information 3h11 CFLAR zymogen caspase-8:c-flipl protease domain complex 1.9Å AUTH J.W.YU,P.D.JEFFREY,Y.SHITITL MECHANISM OF PROCASPASE-8 ACTIVATION BY C-FLIPL.REF PROC.NATL.ACAD.SCI.USA V. 106 8169 2009REFN ISSN 0027-8424PMID 19416807DOI 10.1073/PNAS.0812453106 Variant Set Distributions Mapped Variants
General Structure Information 3gkh NPC1 npc1(ntd) 1.81Å AUTH H.J.KWON,L.ABI-MOSLEH,M.L.WANG,J.DEISENHOFER,J.L.GOLDSTEIN,AUTH 2 M.S.BROWN,R.E.INFANTETITL STRUCTURE OF N-TERMINAL DOMAIN OF NPC1 REVEALS DISTINCTTITL 2 SUBDOMAINS FOR BINDING AND TRANSFER OF CHOLESTEROL.REF CELL(CAMBRIDGE,MASS.) V. 137 1213 2009REFN ISSN 0092-8674PMID 19563754DOI 10.1016/J.CELL.2009.03.049 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wfq DHH crystal structure of the n-terminal signalling domain of human dhh without calcium 1.85Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,E.Y.JONES,AUTH 2 C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGAND SEQUESTRATION BYTITL 2 THE HUMAN HEDGEHOG-INTERACTING PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Mapped Variants
General Structure Information 2wl1 MEFV pyrin pryspry domain 1.35Å AUTH C.WEINERT,C.GRUETTER,H.ROSCHITZKI-VOSER,P.R.MITTL,AUTH 2 M.G.GRUETTERTITL THE CRYSTAL STRUCTURE OF HUMAN PYRIN B30.2 DOMAIN:TITL 2 IMPLICATIONS FOR MUTATIONS ASSOCIATED WITHTITL 3 FAMILIAL MEDITERRANEAN FEVER.REF J.MOL.BIOL. V. 394 226 2009REFN ISSN 0022-2836PMID 19729025DOI 10.1016/J.JMB.2009.08.059 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vaf CASQ2 crystal structure of human cardiac calsequestrin 3.8Å AUTH E.KIM,B.YOUN,L.KEMPER,C.CAMPBELL,H.MILTING,AUTH 2 M.VARSANYI,C.KANGTITL CHARACTERIZATION OF HUMAN CARDIAC CALSEQUESTRINTITL 2 AND ITS DELETERIOUS MUTANTS.REF J.MOL.BIOL. V. 373 1047 2007REFN ISSN 0022-2836PMID 17881003DOI 10.1016/J.JMB.2007.08.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants