General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]
General Structure Information 4ie5 FTO crystal structure of the human fat mass and obesity associated protein (fto) in complex with n-[(3-hydroxypyridin-2-yl)carbonyl]glycine (md6) 1.95Å AUTH W.S.AIK,M.DEMETRIADES,M.K.K.HAMDAN,E.A.L.BAGG,K.K.YEOH,AUTH 2 C.LEJEUNE,Z.ZHANG,M.A.MCDONOUGH,C.J.SCHOFIELDTITL STRUCTURAL BASIS FOR INHIBITION OF THE FAT MASS AND OBESITYTITL 2 ASSOCIATED PROTEIN (FTO)REF J.MED.CHEM. V. 56 3680 2013REFN ISSN 0022-2623PMID 23547775DOI 10.1021/JM400193D Variant Set Distributions Mapped Variants
General Structure Information 4nj4 ALKBH5 crystal structure of human alkbh5 2.02Å AUTH W.AIK,J.S.SCOTTI,H.CHOI,L.GONG,M.DEMETRIADES,C.J.SCHOFIELD,AUTH 2 M.A.MCDONOUGHTITL STRUCTURE OF HUMAN RNA N6-METHYLADENINE DEMETHYLASE ALKBH5TITL 2 PROVIDES INSIGHTS INTO ITS MECHANISMS OF NUCLEIC ACIDTITL 3 RECOGNITION AND DEMETHYLATION.REF NUCLEIC ACIDS RES. V. 42 4741 2014REFN ISSN 0305-1048PMID 24489119DOI 10.1093/NAR/GKU085 Variant Set Distributions Mapped Variants
General Structure Information 3h8x ALKBH2 structure determination of dna methylation lesions n1-mea and n3-mec in duplex dna using a cross-linked host-guest system 1.95Å AUTH L.LU,C.YI,X.JIAN,G.ZHENG,C.HETITL STRUCTURE DETERMINATION OF DNA METHYLATION LESIONS N1-MEATITL 2 AND N3-MEC IN DUPLEX DNA USING A CROSS-LINKED PROTEIN-DNATITL 3 SYSTEM.REF NUCLEIC ACIDS RES. V. 38 4415 2010REFN ISSN 0305-1048PMID 20223766DOI 10.1093/NAR/GKQ129 […]
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jxj KDM5A nmr structure of the arid domain from the histone h3k4 demethylase rbp2 -1.0Å AUTH S.TU,Y.C.TENG,C.YUAN,Y.T.WU,M.Y.CHAN,A.N.CHENG,AUTH 2 P.H.LIN,L.J.JUAN,M.D.TSAITITL THE ARID DOMAIN OF THE H3K4 DEMETHYLASE RBP2 BINDSTITL 2 TO A DNA CCGCCC MOTIFREF NAT.STRUCT.MOL.BIOL. V. 15 419 2008REFN ISSN 1545-9993PMID 18270511DOI 10.1038/NSMB.1400 Variant Set Distributions Mapped Variants
General Structure Information 3d3l ALOX12 the 2.6 a crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type (casp target) 2.6Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,K.OLESEN,C.PERSSON,J.SAGEMARK,H.SCHUELER,AUTH 7 L.SVENSSON,A.G.THORSELL,S.VAN DEN BERG,M.WELIN,AUTH 8 J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE LIPOXYGENASE DOMAIN OFTITL 2 HUMAN ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE.REF TO BE PUBLISHEDREFN […]
General Structure Information 3o8y ALOX5 stable-5-lipoxygenase 2.39Å AUTH N.C.GILBERT,S.G.BARTLETT,M.T.WAIGHT,D.B.NEAU,W.E.BOEGLIN,AUTH 2 A.R.BRASH,M.E.NEWCOMERTITL THE STRUCTURE OF HUMAN 5-LIPOXYGENASE.REF SCIENCE V. 331 217 2011REFN ISSN 0036-8075PMID 21233389DOI 10.1126/SCIENCE.1197203 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants