Assessment of Structural Intolerance and Durability
General Structure Information 3g1n HUWE1 catalytic domain of the human e3 ubiquitin-protein ligase huwe1 2.6Å AUTH J.R.WALKER,L.QIU,Y.LI,T.DAVIS,W.TEMPEL,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,AUTH 3 S.DHE-PAGANONTITL HECT DOMAIN OF HUMAN HUWE1/MULEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3um1 BROX crystal structure of the brox bro1 domain in complex with the c- terminal tail of chmp5 2.71Å AUTH R.MU,V.DUSSUPT,J.JIANG,P.SETTE,V.RUDD,W.CHUENCHOR,N.F.BELLO,AUTH 2 F.BOUAMR,T.S.XIAOTITL TWO DISTINCT BINDING MODES DEFINE THE INTERACTION OF BROXTITL 2 WITH THE C-TERMINAL TAILS OF CHMP5 AND CHMP4B.REF STRUCTURE V. 20 887 2012REFN ISSN 0969-2126PMID 22484091DOI 10.1016/J.STR.2012.03.001 Variant Set […]
General Structure Information 3tw8 DENND1B gef domain of dennd 1b in complex with rab gtpase rab35 2.1Å AUTH X.WU,M.J.BRADLEY,Y.CAI,D.KUMMEL,E.M.DE LA CRUZ,F.A.BARR,AUTH 2 K.M.REINISCHTITL INSIGHTS REGARDING GUANINE NUCLEOTIDE EXCHANGE FROM THETITL 2 STRUCTURE OF A DENN-DOMAIN PROTEIN COMPLEXED WITH ITS RABTITL 3 GTPASE SUBSTRATE.REF PROC.NATL.ACAD.SCI.USA V. 108 18672 2011REFN ISSN 0027-8424PMID 22065758DOI 10.1073/PNAS.1110415108 Variant Set Distributions […]
General Structure Information 3s8p SUV420H1 crystal structure of the set domain of human histone-lysine n- methyltransferase suv420h1 in complex with s-adenosyl-l-methionine 1.85Å AUTH H.WU,A.SIARHEYEVA,H.ZENG,R.LAM,A.DONG,X.H.WU,Y.LI,AUTH 2 M.SCHAPIRA,M.VEDADI,J.MINTITL CRYSTAL STRUCTURES OF THE HUMAN HISTONE H4K20TITL 2 METHYLTRANSFERASES SUV420H1 AND SUV420H2.REF FEBS LETT. V. 587 3859 2013REFN ISSN 0014-5793PMID 24396869 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4hpl BCOR pcgf1 ub fold (rawul)/bcor pufd complex 2.0Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1w6u DECR1 structure of human decr ternary complex 1.75Å AUTH M.S.ALPHEY,W.YU,E.BYRES,D.LI,W.N.HUNTERTITL STRUCTURE AND REACTIVITY OF HUMAN MITOCHONDRIALTITL 2 2,4-DIENOYL-COA REDUCTASE: ENZYME-LIGANDTITL 3 INTERACTIONS IN A DISTINCTIVE SHORT-CHAINTITL 4 REDUCTASE ACTIVE SITEREF J.BIOL.CHEM. V. 280 3068 2005REFN ISSN 0021-9258PMID 15531764DOI 10.1074/JBC.M411069200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4nm6 TET2 crystal structure of tet2-dna complex 2.03Å AUTH L.HU,Z.LI,J.CHENG,Q.RAO,W.GONG,M.LIU,Y.G.SHI,J.ZHU,P.WANG,AUTH 2 Y.XUTITL CRYSTAL STRUCTURE OF TET2-DNA COMPLEX: INSIGHT INTOTITL 2 TET-MEDIATED 5MC OXIDATION.REF CELL(CAMBRIDGE,MASS.) V. 155 1545 2013REFN ISSN 0092-8674PMID 24315485DOI 10.1016/J.CELL.2013.11.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iec MARK2 helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates 2.2Å AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2dha ESRP1 solution structure of the second rna recognition motif in hypothetical protein flj201171 -1.0Å AUTH T.IMAI,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA RECOGNITIONTITL 2 MOTIF IN HYPOTHETICAL PROTEIN FLJ201171REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yuy ARHGAP21 solution structure of pdz domain of rho gtpase activating protein 21 -1.0Å AUTH T.N.NIRAULA,M.YONEYAMA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF PDZ DOMAIN OF RHO GTPASETITL 2 ACTIVATING PROTEIN 21REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants