General Structure Information
| PDB ID | 3g1n |
| HGNC Gene Label(s) | HUWE1 |
| Structure Name | catalytic domain of the human e3 ubiquitin-protein ligase huwe1 |
| Resolution | 2.6Å |
| Reference | AUTH J.R.WALKER,L.QIU,Y.LI,T.DAVIS,W.TEMPEL,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,AUTH 3 S.DHE-PAGANONTITL HECT DOMAIN OF HUMAN HUWE1/MULEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 362 |
| Number Of SNVs | 19 |
| Number Of Permutations | 4213 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.216 |
| p-value | 0.021 |
COSMIC
| Number Of Residues | 362 |
| Number Of SNVs | 4 |
| Number Of Permutations | 115 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.167 |
| p-value | 0.702 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 19 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.146 |
| p-value | 0.784 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
