Assessment of Structural Intolerance and Durability
General Structure Information 4lec METTL21A human methyltransferase-like protein 21a 2.28Å AUTH H.ZENG,A.DONG,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKETITL 2 PROTEIN 21A IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xks NUP133 the crystal structure of the n-terminal domain of nup133 reveals a beta-propeller fold common to several nucleoporins 2.35Å AUTH I.C.BERKE,T.BOEHMER,G.BLOBEL,T.U.SCHWARTZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF NUP133 DOMAINS REVEALSTITL 2 MODULAR BUILDING BLOCKS OF THE NUCLEAR PORE COMPLEX.REF J.CELL BIOL. V. 167 591 2004REFN ISSN 0021-9525PMID 15557116DOI 10.1083/JCB.200408109 Variant Set Distributions […]
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p0k SCMH1 crystal structure of scmh1 1.75Å AUTH N.HERZANYCH,G.SENISTERRA,Y.LIU,L.CROMBET,P.LOPPNAU,AUTH 2 I.KOZIERADZKI,M.VEDADI,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,J.MINTITL STRUCTURE OF SCMH1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l0a STAM solution nmr structure of signal transducing adapter molecule 1 stam-1 from homo sapiens, northeast structural genomics consortium target hr4479e -1.0Å AUTH Y.TANG,H.JANJUA,C.CICCOSANTI,R.SHASTRY,B.ROST,T.B.ACTON,AUTH 2 R.XIAO,J.K.EVERETT,G.T.MONTELIONE,C.H.ARROWSMITHTITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4479EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4m6t LEO1 structure of human paf1 and leo1 complex 2.5Å AUTH X.CHU,X.QIN,H.XU,L.LI,Z.WANG,F.LI,X.XIE,H.ZHOU,Y.SHEN,J.LONGTITL STRUCTURAL INSIGHTS INTO PAF1 COMPLEX ASSEMBLY AND HISTONETITL 2 BINDINGREF NUCLEIC ACIDS RES. V. 41 10619 2013REFN ISSN 0305-1048PMID 24038468DOI 10.1093/NAR/GKT819 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ylm USP7 mechanism of usp7 (hausp) activation by its c-terminal ubiquitin-like domain (hubl) and allosteric regulation by gmp-synthetase. 2.7Å AUTH A.C.FAESEN,A.M.G.DIRAC,A.SHANMUGHAM,H.OVAA,A.PERRAKIS,AUTH 2 T.K.SIXMATITL MECHANISM OF USP7/HAUSP ACTIVATION BY ITS C- TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN AND ALLOSTERIC REGULATION BYTITL 3 GMP-SYNTHETASEREF MOL.CELL V. 44 147 2011REFN ISSN 1097-2765PMID 21981925DOI 10.1016/J.MOLCEL.2011.06.034 Variant Set Distributions […]
General Structure Information 1ury CYGB cytoglobin cavities 2.4Å AUTH D.DE SANCTIS,S.DEWILDE,A.PESCE,L.MOENS,P.ASCENZI,AUTH 2 T.HANKELN,T.BURMESTER,M.BOLOGNESITITL CYTOGLOBIN CAVITIESREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 316 1217 2004REFN ISSN 0006-291XPMID 15044115DOI 10.1016/J.BBRC.2004.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hnm CTNNBL1 crystal structure of human catenin-beta-like 1 56 kda fragment 2.9Å AUTH X.HUANG,G.WANG,Y.WU,Z.DUTITL THE STRUCTURE OF FULL-LENGTH HUMAN CTNNBL1 REVEALS ATITL 2 DISTINCT MEMBER OF THE ARMADILLO-REPEAT PROTEIN FAMILY.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1598 2013REFN ISSN 0907-4449PMID 23897482DOI 10.1107/S0907444913011360 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3nw0 NSMCE1 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants