Assessment of Structural Intolerance and Durability
General Structure Information 3qf2 NLRP3 crystal structure of nalp3 pyd 1.7Å AUTH J.Y.BAE,H.H.PARKTITL CRYSTAL STRUCTURE OF NALP3 PROTEIN PYRIN DOMAIN (PYD) ANDTITL 2 ITS IMPLICATIONS IN INFLAMMASOME ASSEMBLYREF J.BIOL.CHEM. V. 286 39528 2011REFN ISSN 0021-9258PMID 21880711DOI 10.1074/JBC.M111.278812 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b2d CD180 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yde HSD17B14 crystal structure of human retinal short-chain dehydrogenase/reductase 3 2.4Å AUTH P.LUKACIK,B.KELLER,G.BUNKOCZI,K.L.KAVANAGH,K.KAVANAGH,AUTH 2 W.H.LEE,W.HWA LEE,J.ADAMSKI,U.OPPERMANNTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMAN ORPHANTITL 2 DHRS10 REVEALS A NOVEL CYTOSOLIC ENZYME WITH STEROIDTITL 3 DEHYDROGENASE ACTIVITY.REF BIOCHEM.J. V. 402 419 2007REFN ISSN 0264-6021PMID 17067289DOI 10.1042/BJ20061319 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rlo AGAP2 split ph domain of pi3-kinase enhancer -1.0Å AUTH J.YAN,W.WEN,L.N.CHAN,M.ZHANGTITL SPLIT PLECKSTRIN HOMOLOGY DOMAIN-MEDIATEDTITL 2 CYTOPLASMIC-NUCLEAR LOCALIZATION OF PI3-KINASETITL 3 ENHANCER GTPASEREF J.MOL.BIOL. V. 378 425 2008REFN ISSN 0022-2836PMID 18371979DOI 10.1016/J.JMB.2008.02.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2pqf PARP12 human poly(adp-ribose) polymerase 12, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1ou5 TRNT1 crystal structure of human cca-adding enzyme 3.4Å AUTH M.A.AUGUSTIN,A.S.REICHERT,H.BETAT,R.HUBER,M.MOERL,AUTH 2 C.STEEGBORNTITL CRYSTAL STRUCTURE OF THE HUMAN CCA-ADDING ENZYME:TITL 2 INSIGHTS INTO TEMPLATE-INDEPENDENT POLYMERIZATIONREF J.MOL.BIOL. V. 328 985 2003REFN ISSN 0022-2836PMID 12729736DOI 10.1016/S0022-2836(03)00381-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4lt6 PAPOLG crystal structure of human poly(a) polymerase gamma 2.79Å AUTH Q.YANG,L.W.NAUSCH,G.MARTIN,W.KELLER,S.DOUBLIETITL CRYSTAL STRUCTURE OF HUMAN POLY(A) POLYMERASE GAMMA REVEALSTITL 2 A CONSERVED CATALYTIC CORE FOR CANONICAL POLY(A)TITL 3 POLYMERASES.REF J.MOL.BIOL. V. 426 43 2014REFN ISSN 0022-2836PMID 24076191DOI 10.1016/J.JMB.2013.09.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2nsq NEDD4L crystal structure of the c2 domain of the human e3 ubiquitin-protein ligase nedd4-like protein 1.85Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE C2 DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASETITL 2 NEDD4-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2e9x GINS4 the crystal structure of human gins core complex 2.3Å AUTH K.KAMADA,Y.KUBOTA,T.ARATA,Y.SHINDO,F.HANAOKATITL STRUCTURE OF THE HUMAN GINS COMPLEX AND ITSTITL 2 ASSEMBLY AND FUNCTIONAL INTERFACE IN REPLICATIONTITL 3 INITIATIONREF NAT.STRUCT.MOL.BIOL. V. 14 388 2007REFN ISSN 1545-9993PMID 17417653DOI 10.1038/NSMB1231 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3edt KLC2 crystal structure of the mutated s328n hklc2 tpr domain 2.7Å AUTH H.ZHU,Y.SHEN,F.MACKENZIE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF MUTATED S328N TPR DOMAIN OF HUMANTITL 2 KINESIN LIGHT CHAIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants