General Structure Information
| PDB ID | 1yde |
| HGNC Gene Label(s) | HSD17B14 |
| Structure Name | crystal structure of human retinal short-chain dehydrogenase/reductase 3 |
| Resolution | 2.4Å |
| Reference | AUTH P.LUKACIK,B.KELLER,G.BUNKOCZI,K.L.KAVANAGH,K.KAVANAGH,AUTH 2 W.H.LEE,W.HWA LEE,J.ADAMSKI,U.OPPERMANNTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMAN ORPHANTITL 2 DHRS10 REVEALS A NOVEL CYTOSOLIC ENZYME WITH STEROIDTITL 3 DEHYDROGENASE ACTIVITY.REF BIOCHEM.J. V. 402 419 2007REFN ISSN 0264-6021PMID 17067289DOI 10.1042/BJ20061319 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 255 |
| Number Of SNVs | 74 |
| Number Of Permutations | 12266 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.016 |
| p-value | 0.736 |
COSMIC
| Number Of Residues | 255 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1184 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.2 |
| p-value | 0.608 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 74 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.168 |
| p-value | 0.828 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
