General Structure Information
| PDB ID | 3edt |
| HGNC Gene Label(s) | KLC2 |
| Structure Name | crystal structure of the mutated s328n hklc2 tpr domain |
| Resolution | 2.7Å |
| Reference | AUTH H.ZHU,Y.SHEN,F.MACKENZIE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF MUTATED S328N TPR DOMAIN OF HUMANTITL 2 KINESIN LIGHT CHAIN 2REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 250 |
| Number Of SNVs | 56 |
| Number Of Permutations | 41494 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.014 |
| p-value | 0.674 |
COSMIC
| Number Of Residues | 250 |
| Number Of SNVs | 3 |
| Number Of Permutations | 363 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.333 |
| p-value | 0.954 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.326 |
| p-value | 0.867 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
