Assessment of Structural Intolerance and Durability
General Structure Information 2rli SCO2 solution structure of cu(i) human sco2 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,AUTH 2 I.P.GEROTHANASSIS,I.LEONTARI,M.MARTINELLI,S.WANGTITL A STRUCTURAL CHARACTERIZATION OF HUMAN SCO2REF STRUCTURE V. 15 1132 2007REFN ISSN 0969-2126PMID 17850752DOI 10.1016/J.STR.2007.07.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pfn NADK crystal structure of human nad kinase 2.7Å AUTH H.WANG,W.TEMPEL,A.K.WERNIMONT,Y.TONG,X.GUAN,Y.SHEN,Y.LI,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN NAD KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3eh1 SEC24B crystal structure of the human copii-coat protein sec24b 1.8Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEINTITL 2 DISCRIMINATION BY THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2nzj REM1 the crystal structure of rem1 in complex with gdp 2.5Å AUTH A.P.TURNBULL,E.PAPAGRIGORIOU,E.UGOCHUKWU,J.M.ELKINS,AUTH 2 M.SOUNDARARAJAN,X.YANG,F.GORREC,C.UMEANO,E.SALAH,N.BURGESS,AUTH 3 C.JOHANSSON,G.BERRIDGE,O.GILEADI,J.BRAY,B.MARSDEN,S.WATTS,AUTH 4 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,M.SUNDSTROM,AUTH 5 D.DOYLETITL THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kq4 CUBN structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3q32 JAK2 structure of janus kinase 2 with a pyrrolotriazine inhibitor 2.5Å AUTH L.S.HARIKRISHNAN,M.G.KAMAU,H.WAN,J.A.INGHRIM,K.ZIMMERMANN,AUTH 2 X.SANG,H.A.MASTALERZ,W.L.JOHNSON,G.ZHANG,L.J.LOMBARDO,AUTH 3 M.A.POSS,G.L.TRAINOR,J.S.TOKARSKI,M.V.LORENZI,D.YOU,AUTH 4 M.M.GOTTARDIS,K.F.BALDWIN,J.LIPPY,D.S.NIRSCHL,R.QIU,AUTH 5 A.V.MILLER,J.KHAN,J.S.SACK,A.V.PURANDARETITL PYRROLO[1,2-F]TRIAZINES AS JAK2 INHIBITORS: ACHIEVINGTITL 2 POTENCY AND SELECTIVITY FOR JAK2 OVER JAK3.REF BIOORG.MED.CHEM.LETT. V. 21 1425 2011REFN ISSN 0960-894XPMID 21282055DOI 10.1016/J.BMCL.2011.01.022 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4bkw ZFYVE9 crystal structure of the c-terminal region of human zfyve9 2.53Å AUTH E.WILLIAMSTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMAN ZFYVE9REF PH D THESIS 2013PUBL NULL: UNIVERSITY OF OXFORD (THESIS) Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4chb KLHL2 crystal structure of the human klhl2 kelch domain in complex with a wnk4 peptide 1.56Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4jih AKR1B10 crystal structure of akr1b10 complexed with nadp+ and epalrestat 2.3Å AUTH L.ZHANG,H.ZHANG,Y.ZHAO,Z.LI,S.CHEN,J.ZHAI,Y.CHEN,W.XIE,AUTH 2 Z.WANG,Q.LI,X.ZHENG,X.HUTITL INHIBITOR SELECTIVITY BETWEEN ALDO-KETO REDUCTASETITL 2 SUPERFAMILY MEMBERS AKR1B10 AND AKR1B1: ROLE OF TRP112TITL 3 (TRP111).REF FEBS LETT. V. 587 3681 2013REFN ISSN 0014-5793PMID 24100137DOI 10.1016/J.FEBSLET.2013.09.031 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]