General Structure Information
| PDB ID | 4jih |
| HGNC Gene Label(s) | AKR1B10 |
| Structure Name | crystal structure of akr1b10 complexed with nadp+ and epalrestat |
| Resolution | 2.3Å |
| Reference | AUTH L.ZHANG,H.ZHANG,Y.ZHAO,Z.LI,S.CHEN,J.ZHAI,Y.CHEN,W.XIE,AUTH 2 Z.WANG,Q.LI,X.ZHENG,X.HUTITL INHIBITOR SELECTIVITY BETWEEN ALDO-KETO REDUCTASETITL 2 SUPERFAMILY MEMBERS AKR1B10 AND AKR1B1: ROLE OF TRP112TITL 3 (TRP111).REF FEBS LETT. V. 587 3681 2013REFN ISSN 0014-5793PMID 24100137DOI 10.1016/J.FEBSLET.2013.09.031 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 315 |
| Number Of SNVs | 83 |
| Number Of Permutations | 9975 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.242 |
| p-value | 0.457 |
COSMIC
| Number Of Residues | 315 |
| Number Of SNVs | 3 |
| Number Of Permutations | 107 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.667 |
| p-value | 0.136 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.532 |
| p-value | 0.162 |