Assessment of Structural Intolerance and Durability
General Structure Information 1qty FLT1 vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor 2.7Å AUTH M.A.STAROVASNIK,H.W.CHRISTINGER,C.WIESMANN,AUTH 2 M.A.CHAMPE,A.M.DE VOS,N.J.SKELTONTITL SOLUTION STRUCTURE OF THE VEGF-BINDING DOMAIN OFTITL 2 FLT-1: COMPARISON OF ITS FREE AND BOUND STATES.REF J.MOL.BIOL. V. 293 531 1999REFN ISSN 0022-2836PMID 10543948DOI 10.1006/JMBI.1999.3134 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2k21 KCNE1 nmr structure of human kcne1 in lmpg micelles at ph 6.0 and 40 degree c -1.0Å AUTH C.KANG,C.TIAN,F.D.SONNICHSEN,J.A.SMITH,J.MEILER,AUTH 2 A.L.GEORGE,C.G.VANOYE,H.J.KIM,C.R.SANDERSTITL STRUCTURE OF KCNE1 AND IMPLICATIONS FOR HOW ITTITL 2 MODULATES THE KCNQ1 POTASSIUM CHANNEL.REF BIOCHEMISTRY V. 47 7999 2008REFN ISSN 0006-2960PMID 18611041DOI 10.1021/BI800875Q Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3n46 FDPS human fpps complex with nov_980 and zoledronic acid/mg2+ 2.35Å AUTH W.JAHNKE,J.M.RONDEAU,S.COTESTA,A.MARZINZIK,X.PELLE,M.GEISER,AUTH 2 A.STRAUSS,M.GOTTE,F.BITSCH,R.HEMMIG,C.HENRY,S.LEHMANN,AUTH 3 J.F.GLICKMAN,T.P.RODDY,S.J.STOUT,J.R.GREENTITL ALLOSTERIC NON-BISPHOSPHONATE FPPS INHIBITORS IDENTIFIED BYTITL 2 FRAGMENT-BASED DISCOVERY.REF NAT.CHEM.BIOL. V. 6 660 2010REFN ISSN 1552-4450PMID 20711197DOI 10.1038/NCHEMBIO.421 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3azn HIST1H2BJ crystal structure of human nucleosome core particle containing h4k91q mutation 3.0Å AUTH W.IWASAKI,H.TACHIWANA,K.KAWAGUCHI,T.SHIBATA,W.KAGAWA,AUTH 2 H.KURUMIZAKATITL COMPREHENSIVE STRUCTURAL ANALYSIS OF MUTANT NUCLEOSOMESTITL 2 CONTAINING LYSINE TO GLUTAMINE (KQ) SUBSTITUTIONS IN THE H3TITL 3 AND H4 HISTONE-FOLD DOMAINSREF BIOCHEMISTRY V. 50 7822 2011REFN ISSN 0006-2960PMID 21812398DOI 10.1021/BI201021H Variant Set Distributions Ripley’s K […]
General Structure Information 2vdy SERPINA6 crystal structure of the reactive loop cleaved corticosteroid binding globulin complexed with cortisol 2.3Å AUTH A.ZHOU,Z.WEI,P.L.STANLEY,R.J.READ,P.E.STEIN,R.W.CARRELLTITL THE S-TO-R TRANSITION OF CORTICOSTEROID-BINDING GLOBULINTITL 2 AND THE MECHANISM OF HORMONE RELEASE.REF J.MOL.BIOL. V. 380 244 2008REFN ISSN 0022-2836PMID 18513745DOI 10.1016/J.JMB.2008.05.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1r1j MME structural analysis of neprilysin with various specific and potent inhibitors 2.35Å AUTH C.OEFNER,B.P.ROQUES,M.C.FOURNIE-ZALUSKI,G.E.DALETITL STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC ANDTITL 2 POTENT INHIBITORS.REF ACTA CRYSTALLOGR.,SECT.D V. 60 392 2004REFN ISSN 0907-4449PMID 14747736DOI 10.1107/S0907444903027410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1bla FGF2 basic fibroblast growth factor (fgf-2) mutant with cys 78 replaced by ser and cys 96 replaced by ser, nmr -1.0Å AUTH F.J.MOY,A.P.SEDDON,P.BOHLEN,R.POWERSTITL HIGH-RESOLUTION SOLUTION STRUCTURE OF BASICTITL 2 FIBROBLAST GROWTH FACTOR DETERMINED BYTITL 3 MULTIDIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCETITL 4 SPECTROSCOPY.REF BIOCHEMISTRY V. 35 13552 1996REFN ISSN 0006-2960PMID 8885834DOI 10.1021/BI961260P Variant […]
General Structure Information 3bu6 INSR crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide 1.95Å AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4ilw MMP10 complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2) 2.1Å AUTH J.BATRA,A.S.SOARES,C.MEHNER,E.S.RADISKYTITL MATRIX METALLOPROTEINASE-10/TIMP-2 STRUCTURE AND ANALYSESTITL 2 DEFINE CONSERVED CORE INTERACTIONS AND DIVERSE EXOSITETITL 3 INTERACTIONS IN MMP/TIMP COMPLEXES.REF PLOS ONE V. 8 75836 2013REFN ESSN 1932-6203PMID 24073280DOI 10.1371/JOURNAL.PONE.0075836 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4e93 FES crystal structure of human feline sarcoma viral oncogene homologue (v- fes)in complex with tae684 1.84Å AUTH S.HELLWIG,C.V.MIDUTURU,S.KANDA,J.ZHANG,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,X.DENG,H.G.CHOI,W.ZHOU,W.HUR,S.KNAPP,N.S.GRAY,AUTH 3 T.E.SMITHGALLTITL SMALL-MOLECULE INHIBITORS OF THE C-FES PROTEIN-TYROSINETITL 2 KINASE.REF CHEM.BIOL. V. 19 529 2012REFN ISSN 1074-5521PMID 22520759DOI 10.1016/J.CHEMBIOL.2012.01.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]