Assessment of Structural Intolerance and Durability
General Structure Information 2iwg TRIM21 complex between the pryspry domain of trim21 and igg fc 2.35Å AUTH L.C.JAMES,A.H.KEEBLE,Z.KHAN,D.A.RHODES,J.TROWSDALETITL STRUCTURAL BASIS FOR PRYSPRY-MEDIATED TRIPARTITETITL 2 MOTIF (TRIM) PROTEIN FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 6200 2007REFN ISSN 0027-8424PMID 17400754DOI 10.1073/PNAS.0609174104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x9n LIG1 crystal structure of human dna ligase i bound to 5-adenylated, nicked dna 3.0Å AUTH J.M.PASCAL,P.J.OBRIEN,A.E.TOMKINSON,T.ELLENBERGERTITL HUMAN DNA LIGASE I COMPLETELY ENCIRCLES AND PARTIALLYTITL 2 UNWINDS NICKED DNA.REF NATURE V. 432 473 2004REFN ISSN 0028-0836PMID 15565146DOI 10.1038/NATURE03082 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3ry6 FCGR2A complex of fcgammariia (cd32) and the fc of human igg1 3.8Å AUTH P.A.RAMSLAND,W.FARRUGIA,T.M.BRADFORD,C.T.SARDJONO,S.ESPARON,AUTH 2 H.M.TRIST,M.S.POWELL,P.S.TAN,A.C.CENDRON,B.D.WINES,AUTH 3 A.M.SCOTT,P.M.HOGARTHTITL STRUCTURAL BASIS FOR FC{GAMMA}RIIA RECOGNITION OF HUMAN IGGTITL 2 AND FORMATION OF INFLAMMATORY SIGNALING COMPLEXES.REF J.IMMUNOL. V. 187 3208 2011REFN ISSN 0022-1767PMID 21856937DOI 10.4049/JIMMUNOL.1101467 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2alr AKR1A1 aldehyde reductase 2.48Å AUTH O.EL-KABBANI,N.C.GREEN,G.LIN,M.CARSON,S.V.NARAYANA,AUTH 2 K.M.MOORE,T.G.FLYNN,L.J.DELUCASTITL STRUCTURES OF HUMAN AND PORCINE ALDEHYDETITL 2 REDUCTASE: AN ENZYME IMPLICATED IN DIABETICTITL 3 COMPLICATIONS.REF ACTA CRYSTALLOGR.,SECT.D V. 50 859 1994REFN ISSN 0907-4449PMID 15299353DOI 10.1107/S0907444994005275 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1a7s AZU1 atomic resolution structure of hbp 1.12Å AUTH S.KARLSEN,L.F.IVERSEN,I.K.LARSEN,H.J.FLODGAARD,J.S.KASTRUPTITL ATOMIC RESOLUTION STRUCTURE OF HUMAN HBP/CAP37/AZUROCIDIN.REF ACTA CRYSTALLOGR.,SECT.D V. 54 598 1998REFN ISSN 0907-4449PMID 9761855DOI 10.1107/S0907444997016193 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ypa TAL1 structure of the scl:e47:lmo2:ldb1 complex bound to dna 2.8Å AUTH K.EL OMARI,S.J.HOOSDALLY,K.TULADHAR,D.KARIA,E.HALL-PONSELE,AUTH 2 O.PLATONOVA,P.VYAS,R.PATIENT,C.PORCHER,E.J.MANCINITITL STRUCTURAL BASIS FOR LMO2-DRIVEN RECRUITMENT OF THETITL 2 SCL:E47BHLH HETERODIMER TO HEMATOPOIETIC-SPECIFICTITL 3 TRANSCRIPTIONAL TARGETS.REF CELL REP. V. 4 135 2013REFN ISSN 2211-1247PMID 23831025DOI 10.1016/J.CELREP.2013.06.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3hng FLT1 crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide 2.7Å AUTH L.TRESAUGUES,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,T.NYMAN,C.PERSSON,T.KRAGH-NIELSEN,AUTH 5 A.KOTZCH,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,S.VAN DER BERG,J.WEIGELT,M.WELIN,AUTH 7 M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITHTITL 2 N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3vwk CD1D ternary crystal structure of the human nkt tcr-cd1d-4deoxy-alpha- galactosylceramide complex 2.94Å AUTH K.S.WUN,F.ROSS,O.PATEL,G.S.BESRA,S.A.PORCELLI,AUTH 2 S.K.RICHARDSON,S.KESHIPEDDY,A.R.HOWELL,D.I.GODFREY,AUTH 3 J.ROSSJOHNTITL HUMAN AND MOUSE TYPE I NATURAL KILLER T CELL ANTIGENTITL 2 RECEPTORS EXHIBIT DIFFERENT FINE SPECIFICITIES FORTITL 3 CD1D-ANTIGEN COMPLEXREF J.BIOL.CHEM. V. 287 39139 2012REFN ISSN 0021-9258PMID 22995911DOI 10.1074/JBC.M112.412320 Variant Set Distributions Ripley’s […]
General Structure Information 3lqz HLA-DPA1 crystal structure of hla-dp2 3.25Å AUTH S.DAI,G.A.MURPHY,F.CRAWFORD,D.G.MACK,M.T.FALTA,P.MARRACK,AUTH 2 J.W.KAPPLER,A.P.FONTENOTTITL CRYSTAL STRUCTURE OF HLA-DP2 AND IMPLICATIONS FOR CHRONICTITL 2 BERYLLIUM DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 107 7425 2010REFN ISSN 0027-8424PMID 20356827DOI 10.1073/PNAS.1001772107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1b72 HOXB1 pbx1, homeobox protein hox-b1/dna ternary complex 2.35Å AUTH D.E.PIPER,A.H.BATCHELOR,C.P.CHANG,M.L.CLEARY,AUTH 2 C.WOLBERGERTITL STRUCTURE OF A HOXB1-PBX1 HETERODIMER BOUND TOTITL 2 DNA: ROLE OF THE HEXAPEPTIDE AND A FOURTHTITL 3 HOMEODOMAIN HELIX IN COMPLEX FORMATION.REF CELL(CAMBRIDGE,MASS.) V. 96 587 1999REFN ISSN 0092-8674PMID 10052460DOI 10.1016/S0092-8674(00)80662-5 Variant Set Distributions Ripley’s K Analysis Plots Variant […]