General Structure Information
| PDB ID | 2alr |
| HGNC Gene Label(s) | AKR1A1 |
| Structure Name | aldehyde reductase |
| Resolution | 2.48Å |
| Reference | AUTH O.EL-KABBANI,N.C.GREEN,G.LIN,M.CARSON,S.V.NARAYANA,AUTH 2 K.M.MOORE,T.G.FLYNN,L.J.DELUCASTITL STRUCTURES OF HUMAN AND PORCINE ALDEHYDETITL 2 REDUCTASE: AN ENZYME IMPLICATED IN DIABETICTITL 3 COMPLICATIONS.REF ACTA CRYSTALLOGR.,SECT.D V. 50 859 1994REFN ISSN 0907-4449PMID 15299353DOI 10.1107/S0907444994005275 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 312 |
| Number Of SNVs | 91 |
| Number Of Permutations | 10332 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.202 |
| p-value | 0.164 |
COSMIC
| Number Of Residues | 312 |
| Number Of SNVs | 4 |
| Number Of Permutations | 28 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.167 |
| p-value | 0.28 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 91 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.535 |
| p-value | 0.012 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
