Assessment of Structural Intolerance and Durability
General Structure Information 2v9y GART human aminoimidazole ribonucleotide synthetase 2.1Å AUTH M.WELIN,J.G.GROSSMANN,S.FLODIN,T.NYMAN,P.STENMARK,AUTH 2 L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,P.NORDLUND,L.LEHTIOTITL STRUCTURAL STUDIES OF TRI-FUNCTIONAL HUMAN GART.REF NUCLEIC ACIDS RES. V. 38 7308 2010REFN ISSN 0305-1048PMID 20631005DOI 10.1093/NAR/GKQ595 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fs7 CRABP2 crystal structure of apo-cellular retinoic acid binding protein type ii at 1.55 angstroms resolution 1.55Å AUTH S.VAEZESLAMI,E.MATHES,C.VASILEIOU,B.BORHAN,AUTH 2 J.H.GEIGERTITL THE STRUCTURE OF APO-WILD-TYPE CELLULAR RETINOICTITL 2 ACID BINDING PROTEIN II AT 1.4 A AND ITSTITL 3 RELATIONSHIP TO LIGAND BINDING AND NUCLEARTITL 4 TRANSLOCATION.REF J.MOL.BIOL. V. 363 687 2006REFN ISSN […]
General Structure Information 3e4c CASP1 procaspase-1 zymogen domain crystal strucutre 2.05Å AUTH J.M.ELLIOTT,L.ROUGE,C.WIESMANN,J.M.SCHEERTITL CRYSTAL STRUCTURE OF PROCASPASE-1 ZYMOGEN DOMAIN REVEALSTITL 2 INSIGHT INTO INFLAMMATORY CASPASE AUTOACTIVATIONREF J.BIOL.CHEM. V. 284 6546 2009REFN ISSN 0021-9258PMID 19117953DOI 10.1074/JBC.M806121200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nn6 CMA1 human pro-chymase 1.75Å AUTH K.K.REILING,J.KRUCINSKI,L.J.MIERCKE,W.W.RAYMOND,G.H.CAUGHEY,AUTH 2 R.M.STROUDTITL STRUCTURE OF HUMAN PRO-CHYMASE: A MODEL FOR THE ACTIVATINGTITL 2 TRANSITION OF GRANULE-ASSOCIATED PROTEASES.REF BIOCHEMISTRY V. 42 2616 2003REFN ISSN 0006-2960PMID 12614156DOI 10.1021/BI020594D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1bnd BDNF structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer 2.3Å AUTH R.C.ROBINSON,C.RADZIEJEWSKI,D.I.STUART,E.Y.JONESTITL STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHICTITL 2 FACTOR/NEUROTROPHIN 3 HETERODIMER.REF BIOCHEMISTRY V. 34 4139 1995REFN ISSN 0006-2960PMID 7703225DOI 10.1021/BI00013A001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2uur COL9A1 n-terminal nc4 domain of collagen ix 1.8Å AUTH V.-M.LEPPANEN,H.TOSSAVAINEN,P.PERMI,L.LEHTIO,AUTH 2 G.RONNHOLM,A.GOLDMAN,I.KILPELAINEN,T.PIHLAJAMAATITL CRYSTAL STRUCTURE OF THE N-TERMINAL NC4 DOMAIN OFTITL 2 COLLAGEN IX, A ZINC BINDING MEMBER OF THE LAMININ-TITL 3 NEUREXIN-SEX HORMONE BINDING GLOBULIN (LNS) DOMAINTITL 4 FAMILY.REF J.BIOL.CHEM. V. 282 23219 2007REFN ISSN 0021-9258PMID 17553797DOI 10.1074/JBC.M702514200 Variant Set Distributions […]
General Structure Information 3fe4 CA6 crystal structure of human carbonic anhydrase vi 1.9Å AUTH E.S.PILKA,G.KOCHAN,U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURE OF THE SECRETORY ISOZYME OF MAMMALIANTITL 2 CARBONIC ANHYDRASES CA VI: IMPLICATIONS FOR BIOLOGICALTITL 3 ASSEMBLY AND INHIBITOR DEVELOPMENTREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 419 485 2012REFN ISSN 0006-291XPMID 22366092DOI 10.1016/J.BBRC.2012.02.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1m5i APC crystal structure of the coiled coil region 129-250 of the tumor suppressor gene product apc 2.0Å AUTH L.TICKENBROCK,J.CRAMER,I.R.VETTER,O.MULLERTITL THE COILED COIL REGION (AMINO ACIDS 129-250) OFTITL 2 THE TUMOR SUPPRESSOR PROTEIN ADENOMATOUS POLYPOSISTITL 3 COLI (APC). ITS STRUCTURE AND ITS INTERACTION WITHTITL 4 CHROMOSOME MAINTENANCE REGION 1 (CRM-1).REF J.BIOL.CHEM. V. […]
General Structure Information 3k72 ITGAX structure of integrin alphax beta2 3.7Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1cnt CNTF ciliary neurotrophic factor 2.4Å AUTH N.Q.MCDONALD,N.PANAYOTATOS,W.A.HENDRICKSONTITL CRYSTAL STRUCTURE OF DIMERIC HUMAN CILIARYTITL 2 NEUROTROPHIC FACTOR DETERMINED BY MAD PHASING.REF EMBO J. V. 14 2689 1995REFN ISSN 0261-4189PMID 7796798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants