Assessment of Structural Intolerance and Durability
General Structure Information 2oob CBLB crystal structure of the uba domain from cbl-b ubiquitin ligase in complex with ubiquitin 1.9Å AUTH P.PESCHARD,G.KOZLOV,T.LIN,I.A.MIRZA,A.M.BERGHUIS,AUTH 2 S.LIPKOWITZ,M.PARK,K.GEHRINGTITL STRUCTURAL BASIS FOR UBIQUITIN-MEDIATEDTITL 2 DIMERIZATION AND ACTIVATION OF THE UBIQUITINTITL 3 PROTEIN LIGASE CBL-B.REF MOL.CELL V. 27 474 2007REFN ISSN 1097-2765PMID 17679095DOI 10.1016/J.MOLCEL.2007.06.023 Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC9 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3qx3 TOP2B human topoisomerase iibeta in complex with dna and etoposide 2.16Å AUTH C.C.WU,T.K.LI,L.FARH,L.Y.LIN,T.S.LIN,Y.J.YU,T.J.YEN,AUTH 2 C.W.CHIANG,N.L.CHANTITL STRUCTURAL BASIS OF TYPE II TOPOISOMERASE INHIBITION BY THETITL 2 ANTICANCER DRUG ETOPOSIDEREF SCIENCE V. 333 459 2011REFN ISSN 0036-8075PMID 21778401DOI 10.1126/SCIENCE.1204117 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1cf4 TNK2 cdc42/ack gtpase-binding domain complex -1.0Å AUTH H.R.MOTT,D.OWEN,D.NIETLISPACH,P.N.LOWE,E.MANSER,AUTH 2 L.LIM,E.D.LAUETITL STRUCTURE OF THE SMALL G PROTEIN CDC42 BOUND TOTITL 2 THE GTPASE-BINDING DOMAIN OF ACK.REF NATURE V. 399 384 1999REFN ISSN 0028-0836PMID 10360579DOI 10.1038/20732 Variant Set Distributions Mapped Variants
General Structure Information 4lce CTBP1 ctbp1 in complex with substrate mtob 2.38Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2leb SRSF2 solution structure of human srsf2 (sc35) rrm in complex with 5- uccagu-3 -1.0Å AUTH G.M.DAUBNER,A.CLERY,S.JAYNE,J.STEVENIN,F.H.ALLAINTITL A SYN-ANTI CONFORMATIONAL DIFFERENCE ALLOWS SRSF2 TOTITL 2 RECOGNIZE GUANINES AND CYTOSINES EQUALLY WELL.REF EMBO J. V. 31 162 2012REFN ISSN 0261-4189PMID 22002536DOI 10.1038/EMBOJ.2011.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4b4c CHD1 crystal structure of the dna-binding domain of human chd1. 1.62Å AUTH C.K.ALLERSTON,C.D.O.COOPER,L.SHRESTHA,M.VOLLMAR,AUTH 2 N.BURGESS-BROWN,W.W.YUE,E.P.CARPENTER,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k0v TEK structural basis for angiopoietin-1 mediated signaling initiation 4.51Å AUTH X.YU,T.C.SEEGAR,A.C.DALTON,D.TZVETKOVA-ROBEV,Y.GOLDGUR,AUTH 2 K.R.RAJASHANKAR,D.B.NIKOLOV,W.A.BARTONTITL STRUCTURAL BASIS FOR ANGIOPOIETIN-1-MEDIATED SIGNALINGTITL 2 INITIATION.REF PROC.NATL.ACAD.SCI.USA V. 110 7205 2013REFN ISSN 0027-8424PMID 23592718DOI 10.1073/PNAS.1216890110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants