Assessment of Structural Intolerance and Durability
General Structure Information 2lk9 BST2 structure of bst-2/tetherin transmembrane domain -1.0Å AUTH M.SKASKO,Y.WANG,Y.TIAN,A.TOKAREV,J.MUNGUIA,A.RUIZ,AUTH 2 E.B.STEPHENS,S.J.OPELLA,J.GUATELLITITL HIV-1 VPU PROTEIN ANTAGONIZES INNATE RESTRICTION FACTORTITL 2 BST-2 VIA LIPID-EMBEDDED HELIX-HELIX INTERACTIONS.REF J.BIOL.CHEM. V. 287 58 2012REFN ISSN 0021-9258PMID 22072710DOI 10.1074/JBC.M111.296772 Variant Set Distributions Mapped Variants
General Structure Information 2gf5 FADD structure of intact fadd (mort1) -1.0Å AUTH P.E.CARRINGTON,C.SANDU,Y.WEI,J.M.HILL,G.MORISAWA,AUTH 2 T.HUANG,E.GAVATHIOTIS,Y.WEI,M.H.WERNERTITL THE STRUCTURE OF FADD AND ITS MODE OF INTERACTIONTITL 2 WITH PROCASPASE-8REF MOL.CELL V. 22 599 2006REFN ISSN 1097-2765PMID 16762833DOI 10.1016/J.MOLCEL.2006.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vyx DHX9 structural insights into risc assembly facilitated by dsrna binding domains of human rna helicase (dhx9) 2.29Å AUTH Q.FU,Y.A.YUANTITL STRUCTURAL INSIGHTS INTO RISC ASSEMBLY FACILITATED BYTITL 2 DSRNA-BINDING DOMAINS OF HUMAN RNA HELICASE A (DHX9)REF NUCLEIC ACIDS RES. 2013REFN ESSN 1362-4962PMID 23361462DOI 10.1093/NAR/GKT042 Variant Set Distributions Mapped Variants
General Structure Information 3s97 CNTN1 ptprz cntn1 complex 2.3Å AUTH S.LAMPRIANOU,E.CHATZOPOULOU,J.L.THOMAS,S.BOUYAIN,S.HARROCHTITL A COMPLEX BETWEEN CONTACTIN-1 AND THE PROTEIN TYROSINETITL 2 PHOSPHATASE PTPRZ CONTROLS THE DEVELOPMENT OFTITL 3 OLIGODENDROCYTE PRECURSOR CELLS.REF PROC.NATL.ACAD.SCI.USA V. 108 17498 2011REFN ISSN 0027-8424PMID 21969550DOI 10.1073/PNAS.1108774108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qt2 IL5RA structure of a cytokine ligand-receptor complex 2.55Å AUTH E.PATINO,A.KOTZSCH,S.SAREMBA,J.NICKEL,W.SCHMITZ,W.SEBALD,AUTH 2 T.D.MUELLERTITL STRUCTURE ANALYSIS OF THE IL-5 LIGAND-RECEPTOR COMPLEXTITL 2 REVEALS A WRENCH-LIKE ARCHITECTURE FOR IL-5RALPHA.REF STRUCTURE V. 19 1864 2011REFN ISSN 0969-2126PMID 22153509DOI 10.1016/J.STR.2011.08.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1n0w RAD51 crystal structure of a rad51-brca2 brc repeat complex 1.7Å AUTH L.PELLEGRINI,D.S.YU,T.LO,S.ANAND,M.LEE,AUTH 2 T.L.BLUNDELL,A.R.VENKITARAMANTITL INSIGHTS INTO DNA RECOMBINATION FROM THE STRUCTURETITL 2 OF A RAD51-BRCA2 COMPLEXREF NATURE V. 420 287 2002REFN ISSN 0028-0836PMID 12442171DOI 10.1038/NATURE01230 Variant Set Distributions Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3vhx KIF23 the crystal structure of arf6-mklp1 (mitotic kinesin-like protein 1) complex 2.81Å AUTH H.MAKYIO,M.OHGI,T.TAKEI,S.TAKAHASHI,H.TAKATSU,Y.KATOH,AUTH 2 A.HANAI,T.UEDA,Y.KANAHO,Y.XIE,H.W.SHIN,H.KAMIKUBO,M.KATAOKA,AUTH 3 M.KAWASAKI,R.KATO,S.WAKATSUKI,K.NAKAYAMATITL STRUCTURAL BASIS FOR ARF6-MKLP1 COMPLEX FORMATION ON THETITL 2 FLEMMING BODY RESPONSIBLE FOR CYTOKINESISREF EMBO J. V. 31 2590 2012REFN ISSN 0261-4189PMID 22522702DOI 10.1038/EMBOJ.2012.89 Variant Set Distributions Mapped Variants
General Structure Information 1t5c CENPE crystal structure of the motor domain of human kinetochore protein cenp-e 2.5Å AUTH I.GARCIA-SAEZ,T.YEN,R.H.WADE,F.KOZIELSKITITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF THE HUMANTITL 2 KINETOCHORE PROTEIN CENP-E.REF J.MOL.BIOL. V. 340 1107 2004REFN ISSN 0022-2836PMID 15236970DOI 10.1016/J.JMB.2004.05.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]